| A Critical Review of the Use of Carvedilol in Ischemic Heart Disease. | |
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MedLine Citation:
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PMID: 23061698 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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β-Adrenergic receptor antagonists (β-blockers) have been recognized for their cardioprotective properties, prompting use of these pharmacologic agents to become more mainstream in acute myocardial infarction (AMI) and congestive heart failure (CHF). Despite their popularity as a class, the ability to protect the myocardium varies significantly between different agents. Carvedilol is a non-selective β-blocker with α(1)-adrenergic receptor antagonism properties. It is unique among β-blockers because in addition to improving exercise tolerance and its anti-ischemic properties secondary to a reduction in heart rate and myocardial contractility, carvedilol exerts other beneficial effects including: antioxidant effects; reduction in neutrophil infiltration; apoptosis inhibition; reduction of vascular smooth muscle migration; and improvement of myocardial remodeling post-AMI. These properties, documented in animal models and subsequent clinical trials, are consistent with established evidence demonstrating decreased morbidity and mortality in patients with CHF and post-AMI. This article reviews the role of carvedilol compared with other β-blockers in the treatment of CHF and post-AMI management. |
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Authors:
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Carol Chen-Scarabelli; Louis Saravolatz; Yahya Murad; Wen-Shi Shieh; Waqas Qureshi; Justin Di Rezze; Rodeo Abrencillo; Tova Gardin; Umesh K Gidwani; Louis Saravolatz; Giuseppe Faggian; Tiziano M Scarabelli |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-15 |
Journal Detail:
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Title: American journal of cardiovascular drugs : drugs, devices, and other interventions Volume: - ISSN: 1179-187X ISO Abbreviation: Am J Cardiovasc Drugs Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100967755 Medline TA: Am J Cardiovasc Drugs Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Center for Heart and Vessel Preclinical Studies, St John Hospital and Medical Center, Wayne State University School of Medicine, Detroit, MI, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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