Document Detail


Critical differences in hematopoiesis and lymphoid development between humans and mice.
MedLine Citation:
PMID:  23274800     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During the last five decades, elegant mouse models of hematopoiesis have yielded most of the seminal insights into this complex biological system of self-renewal and lineage commitment. More recent advances in assays to measure human stem and progenitor cells as well as high resolution RNA profiling have revealed that although the basic roadmap of blood development is generally conserved across mammals, evolutionary pressures have generated many differences between the species that have important biological and translational implications. To enhance the utility of the mouse as a model organism, it is more important than ever that research data are presented with regard to how they might be influenced by the species of origin as well as the developmental source of the hematopoietic tissue.
Authors:
Chintan Parekh; Gay M Crooks
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-12-30
Journal Detail:
Title:  Journal of clinical immunology     Volume:  33     ISSN:  1573-2592     ISO Abbreviation:  J. Clin. Immunol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-22     Completed Date:  2013-11-11     Revised Date:  2014-07-04    
Medline Journal Info:
Nlm Unique ID:  8102137     Medline TA:  J Clin Immunol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  711-5     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation
Cell Lineage
Disease Models, Animal
Gene Expression Profiling
Hematopoiesis / immunology*
High-Throughput Nucleotide Sequencing
Humans
Lymphocytes / immunology*
Lymphoid Progenitor Cells / immunology*
Mice
Species Specificity
Grant Support
ID/Acronym/Agency:
1P01AI072686/AI/NIAID NIH HHS; P01 AI072686/AI/NIAID NIH HHS; P01 HL073104/HL/NHLBI NIH HHS; P01 HL073104/HL/NHLBI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Functional connectivity changes in second language vocabulary learning.
Next Document:  IL-17 Level in Patients with Dengue Virus Infection & its Association with Severity of Illness.