Document Detail

Critical comparisons of the clinical performance of oxygen-conserving devices.
MedLine Citation:
PMID:  20133925     Owner:  NLM     Status:  MEDLINE    
RATIONALE: Clinical testing of oxygen-conserving devices is not mandated before marketing. Consequently, little is known about individual or comparative therapeutic effectiveness.
OBJECTIVES: To relate oxygen delivery from prototypical instruments to physiological performance.
METHODS: Thirteen subjects with obstructive lung disease performed progressive treadmill exercise while inhaling either room air, 2 L O(2)/min, or bolus oxygen from four commercially available conserving devices at regulator settings of 2, 5, and continuous. The devices were studied blindly in random order after first being tested to determine performance characteristics. Pulse oximetry, oxygen delivery, and nasal and oral ventilations were monitored at rest and with exertion.
MEASUREMENTS AND MAIN RESULTS: At a setting of 2 at rest, all conservers maintained saturation greater than 90%, but there were significant differences in oxygenation between systems. Only one equaled 2 L O(2)/min. With exertion, saturation decreased with all conservers but not with 2 L O(2)/min. One device did not perform any better than room air. Two systems provided less oxygen than predicted, one more, and in one the expected and actual amounts were equal only at rest. Breath-by-breath performance was highly variable, with irregular activation and inconsistent oxygen bolus size delivery. Increasing oxygen pulse volume to the point of eradicating conservation with the continuous setting did not eliminate all disparities.
CONCLUSIONS: The mechanical and clinical performances of current oxygen conservers are highly variable and in some instances actually contribute to limitations in exercise ability. Seemingly equivalent technical features do not guarantee equivalent therapeutic functionality.
Aishwarya Palwai; Mary Skowronski; Albert Coreno; Colin Drummond; E R McFadden
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2010-02-04
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  181     ISSN:  1535-4970     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-12     Completed Date:  2010-06-09     Revised Date:  2011-07-28    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1061-71     Citation Subset:  AIM; IM    
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine of MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109, USA.
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MeSH Terms
Double-Blind Method
Equipment Design
Exercise Test
Forced Expiratory Volume
Middle Aged
Oxygen / administration & dosage*
Oxygen Inhalation Therapy / instrumentation*
Partial Pressure
Pulmonary Disease, Chronic Obstructive / metabolism,  physiopathology,  therapy*
Sickness Impact Profile
Reg. No./Substance:

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