Document Detail


Crimean-Congo hemorrhagic fever.
MedLine Citation:
PMID:  17762783     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: Crimean-Congo hemorrhagic fever is a tick-borne viral zoonosis with the potential of human-to-human transmission, affecting wide areas in Asia, Southeastern Europe, and Africa. Hemorrhagic manifestations constitute a prominent symptom of late stage disease with case fatality rates from 10% to 50%. The purpose of this article is to review recent literature on Crimean-Congo hemorrhagic fever with emphasis on its epidemiology and management. RECENT FINDINGS: Climate and environmental changes may affect Crimean-Congo hemorrhagic fever epidemiology and trigger community outbreaks. Risk factors for acquisition of infection have been well studied. In the hospital, high-risk activities include interventions for gastrointestinal bleeding and needle stick injuries. Reverse transcription-polymerase chain reaction may rapidly diagnose Crimean-Congo hemorrhagic fever with high sensitivity and specificity. Ribavirin is the only promising therapeutic agent currently available but case-control studies have not been conducted. Recently, the Mx proteins have been found to act against Crimean-Congo hemorrhagic fever virus and deserve further research. SUMMARY: Clinicians should be aware of the potential of importation of Crimean-Congo hemorrhagic fever cases from endemic areas and nosocomial transmission. Studies on the efficacy of ribavirin are needed.
Authors:
Regina Vorou; Ioannis N Pierroutsakos; Helen C Maltezou
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current opinion in infectious diseases     Volume:  20     ISSN:  0951-7375     ISO Abbreviation:  Curr. Opin. Infect. Dis.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-08-31     Completed Date:  2007-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809878     Medline TA:  Curr Opin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  495-500     Citation Subset:  IM    
Affiliation:
Office for Zoonoses and Foodborne Diseases, Athens, Greece.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antiviral Agents / therapeutic use
Hemorrhagic Fever Virus, Crimean-Congo* / genetics,  isolation & purification,  physiology
Hemorrhagic Fever, Crimean* / diagnosis,  drug therapy,  epidemiology,  virology
Humans
Ribavirin / therapeutic use*
Ticks
Zoonoses
Chemical
Reg. No./Substance:
0/Antiviral Agents; 36791-04-5/Ribavirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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