| Crimean-Congo hemorrhagic fever. | |
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MedLine Citation:
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PMID: 17762783 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: Crimean-Congo hemorrhagic fever is a tick-borne viral zoonosis with the potential of human-to-human transmission, affecting wide areas in Asia, Southeastern Europe, and Africa. Hemorrhagic manifestations constitute a prominent symptom of late stage disease with case fatality rates from 10% to 50%. The purpose of this article is to review recent literature on Crimean-Congo hemorrhagic fever with emphasis on its epidemiology and management. RECENT FINDINGS: Climate and environmental changes may affect Crimean-Congo hemorrhagic fever epidemiology and trigger community outbreaks. Risk factors for acquisition of infection have been well studied. In the hospital, high-risk activities include interventions for gastrointestinal bleeding and needle stick injuries. Reverse transcription-polymerase chain reaction may rapidly diagnose Crimean-Congo hemorrhagic fever with high sensitivity and specificity. Ribavirin is the only promising therapeutic agent currently available but case-control studies have not been conducted. Recently, the Mx proteins have been found to act against Crimean-Congo hemorrhagic fever virus and deserve further research. SUMMARY: Clinicians should be aware of the potential of importation of Crimean-Congo hemorrhagic fever cases from endemic areas and nosocomial transmission. Studies on the efficacy of ribavirin are needed. |
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Authors:
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Regina Vorou; Ioannis N Pierroutsakos; Helen C Maltezou |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current opinion in infectious diseases Volume: 20 ISSN: 0951-7375 ISO Abbreviation: Curr. Opin. Infect. Dis. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-08-31 Completed Date: 2007-12-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8809878 Medline TA: Curr Opin Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 495-500 Citation Subset: IM |
Affiliation:
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Office for Zoonoses and Foodborne Diseases, Athens, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antiviral Agents / therapeutic use Hemorrhagic Fever Virus, Crimean-Congo* / genetics, isolation & purification, physiology Hemorrhagic Fever, Crimean* / diagnosis, drug therapy, epidemiology, virology Humans Ribavirin / therapeutic use* Ticks Zoonoses |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 36791-04-5/Ribavirin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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