| Cribrostatin 6 induces death in cancer cells through a reactive oxygen species (ROS)-mediated mechanism. | |
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MedLine Citation:
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PMID: 20169400 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Cribrostatin 6 is a quinone-containing natural product that induces the death of cancer cell lines in culture, and its mechanism of action and scope of activity are unknown. Here we show that cribrostatin 6 has broad anticancer activity, potently inducing apoptotic cell death that is not preceded by any defined cell cycle arrest. Consistent with this data, we find that cribrostatin 6 treated cells have large amounts of reactive oxygen species (ROS) and, based on transcript profiling experiments and other data, this ROS generation is likely the primary mechanism by which cribrostatin 6 induces apoptosis. Given the success of certain ROS producers as anticancer agents, cribrostatin 6 has potential as a novel chemotherapeutic agent. |
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Authors:
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Mirth T Hoyt; Rahul Palchaudhuri; Paul J Hergenrother |
Publication Detail:
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Type: Journal Article Date: 2010-02-20 |
Journal Detail:
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Title: Investigational new drugs Volume: 29 ISSN: 1573-0646 ISO Abbreviation: Invest New Drugs Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-05-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309330 Medline TA: Invest New Drugs Country: United States |
Other Details:
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Languages: eng Pagination: 562-73 Citation Subset: IM |
Affiliation:
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Department of Chemistry, Roger Adams Laboratory, University of Illinois, 600 S Mathews Ave, Urbana, IL, 61801, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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