Document Detail

Creutzfeldt-Jakob disease cluster in an Australian rural city.
MedLine Citation:
PMID:  12112059     Owner:  NLM     Status:  MEDLINE    
Through the Australian National Creutzfeldt-Jakob Disease Registry, 6 pathologically confirmed sporadic cases were recognized over a 13-year period in persons who had been long-term residents of a moderate-sized rural city, whereas the expected number was 0.923. An extensive investigation could not find any point-source or case-to-case transmission links. This occurrence is highly statistically significant (p = 0.0027) when viewed in isolation and remains significant (p < 0.02) when only the cases that arose after the cluster was recognized were taken into account. However, a more conservative statistical analysis suggests that such a grouping could have arisen by chance in at least one population group of this size when the whole country is taken into consideration.
Steven Collins; Alison Boyd; Ashley Fletcher; John Kaldor; Andrew Hill; Stephen Farish; Catriona McLean; Zahid Ansari; Margaret Smith; Colin L Masters
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of neurology     Volume:  52     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-11     Completed Date:  2002-07-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  115-8     Citation Subset:  IM    
Australian National Creutzfeldt-Jakob Disease Registry and Department of Pathology, University of Melbourne, Victoria, Australia.
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MeSH Terms
Australia / epidemiology
Cluster Analysis
Creutzfeldt-Jakob Syndrome / epidemiology*
Middle Aged
Poisson Distribution
Registries / statistics & numerical data
Rural Population* / statistics & numerical data

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