Document Detail

Creola bodies in wheezing infants predict the development of asthma.
MedLine Citation:
PMID:  15059193     Owner:  NLM     Status:  MEDLINE    
Creola bodies (CrBs) have been shown to be present specifically in the sputum of adults with asthma, and are clinically useful in the estimation of airway hyper-responsiveness through correlation with the levels of eosinophil cationic protein in the sputum. Our aim was to investigate whether CrBs can be detected in the sputum of wheezing infants, and the clinical significance of CrBs in wheezing infants in the development of asthma. Twenty-three wheezing infant patients, mean age 5.3 months, were studied. The presence of CrBs in the sputum was determined by Papanicolau's stain. The patients were divided into two groups: CrB positive [CrB(+)] and CrB negative [CrB(-)]. In addition, we examined the relationship between the presence of CrBs and the asthma symptom scores that occurred during a 1-month post-discharge period. The following results were obtained: (i) CrBs were detected in 15 of 23 (65%) wheezing infants; (ii) the asthma symptom scores after discharge was significantly higher in the CrB(+) group than in the CrB(-) group (p < 0.001); (iii) in the infants experiencing their first episode of wheezing, the asthma symptom scores during the post-discharge period was also significantly higher in the CrB(+) group than in the CrB(-) group (p < 0.05). Furthermore, infantile asthma was diagnosed in 12 (80.0%) infants in the CrB(+) group during the following 2-yr period, but none in the CrB(-) group. These findings suggest that CrBs detected in the sputum of wheezing infants may be used to identify the progression to infantile asthma.
Yumi Yamada; Shigemi Yoshihara; Osamu Arisaka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology     Volume:  15     ISSN:  0905-6157     ISO Abbreviation:  Pediatr Allergy Immunol     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-02     Completed Date:  2004-07-22     Revised Date:  2008-05-28    
Medline Journal Info:
Nlm Unique ID:  9106718     Medline TA:  Pediatr Allergy Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  159-62     Citation Subset:  IM    
Department of Pediatrics, Dokkyo University School of Medicine, Mibu, Tochigi Japan.
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MeSH Terms
Asthma / physiopathology*
Disease Progression
Infant, Newborn
Lung Diseases / complications,  physiopathology
Predictive Value of Tests
Respiratory Mucosa / cytology*
Respiratory Sounds / etiology,  physiopathology*
Sputum / cytology*

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