Document Detail


Credneramides A and B: neuromodulatory phenethylamine and isopentylamine derivatives of a vinyl chloride-containing fatty acid from cf. Trichodesmium sp. nov.
MedLine Citation:
PMID:  22148360     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Credneramides A (1) and B (2), two vinyl chloride-containing metabolites, were isolated from a Papua New Guinea collection of cf. Trichodesmium sp. nov. and expand a recently described class of vinyl chloride-containing natural products. The precursor fatty acid, credneric acid (3), was isolated from both the aqueous and organic fractions of the parent fraction as well as from another geographically and phylogenetically distinct cyanobacterial collection (Panama). Credneramides A and B inhibited spontaneous calcium oscillations in murine cerebrocortical neurons at low micromolar concentrations (1, IC(50) 4.0 μM; 2, IC(50) 3.8 μM).
Authors:
Karla L Malloy; Takashi L Suyama; Niclas Engene; Hosana Debonsi; Zhengyu Cao; Teatulohi Matainaho; Carmenza Spadafora; Thomas F Murray; William H Gerwick
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-12-12
Journal Detail:
Title:  Journal of natural products     Volume:  75     ISSN:  1520-6025     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-27     Completed Date:  2012-03-20     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  60-6     Citation Subset:  IM    
Affiliation:
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, California 92093, United States.
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MeSH Terms
Descriptor/Qualifier:
Amines / chemistry,  isolation & purification*,  pharmacology*
Animals
Base Sequence
Cyanobacteria
Fatty Acids / chemistry*,  isolation & purification,  pharmacology*
Mice
Molecular Structure
Neurotransmitter Agents / chemistry,  isolation & purification*,  pharmacology*
Papua New Guinea
Phenethylamines / chemistry,  isolation & purification,  pharmacology*
Quorum Sensing / physiology
Grant Support
ID/Acronym/Agency:
NS 053398/NS/NINDS NIH HHS; R01 NS053398/NS/NINDS NIH HHS; R01 NS053398-11/NS/NINDS NIH HHS; TW006634/TW/FIC NIH HHS; U01 TW006634/TW/FIC NIH HHS; U01 TW006634-10/TW/FIC NIH HHS
Chemical
Reg. No./Substance:
0/Amines; 0/Fatty Acids; 0/Neurotransmitter Agents; 0/Phenethylamines; 0/credneramide A; 0/credneramide B
Comments/Corrections

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