| Credneramides A and B: neuromodulatory phenethylamine and isopentylamine derivatives of a vinyl chloride-containing fatty acid from cf. Trichodesmium sp. nov. | |
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MedLine Citation:
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PMID: 22148360 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Credneramides A (1) and B (2), two vinyl chloride-containing metabolites, were isolated from a Papua New Guinea collection of cf. Trichodesmium sp. nov. and expand a recently described class of vinyl chloride-containing natural products. The precursor fatty acid, credneric acid (3), was isolated from both the aqueous and organic fractions of the parent fraction as well as from another geographically and phylogenetically distinct cyanobacterial collection (Panama). Credneramides A and B inhibited spontaneous calcium oscillations in murine cerebrocortical neurons at low micromolar concentrations (1, IC(50) 4.0 μM; 2, IC(50) 3.8 μM). |
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Authors:
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Karla L Malloy; Takashi L Suyama; Niclas Engene; Hosana Debonsi; Zhengyu Cao; Teatulohi Matainaho; Carmenza Spadafora; Thomas F Murray; William H Gerwick |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-12-12 |
Journal Detail:
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Title: Journal of natural products Volume: 75 ISSN: 1520-6025 ISO Abbreviation: J. Nat. Prod. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-27 Completed Date: 2012-03-20 Revised Date: 2012-04-25 |
Medline Journal Info:
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Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: United States |
Other Details:
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Languages: eng Pagination: 60-6 Citation Subset: IM |
Affiliation:
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Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, California 92093, United States. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amines
/
chemistry,
isolation & purification*,
pharmacology* Animals Base Sequence Cyanobacteria Fatty Acids / chemistry*, isolation & purification, pharmacology* Mice Molecular Structure Neurotransmitter Agents / chemistry, isolation & purification*, pharmacology* Papua New Guinea Phenethylamines / chemistry, isolation & purification, pharmacology* Quorum Sensing / physiology |
| Grant Support | |
ID/Acronym/Agency:
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NS 053398/NS/NINDS NIH HHS; TW006634/TW/FIC NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amines; 0/Fatty Acids; 0/Neurotransmitter Agents; 0/Phenethylamines; 0/credneramide A; 0/credneramide B |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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