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Creatinine reference values in ELBW infants: impact of quantification by Jaffe or enzymatic method.
MedLine Citation:
PMID:  22273037     Owner:  NLM     Status:  Publisher    
Abstract Objective: Creatinine (Scr) reflects to a certain extent glomerular filtration rate in neonates, but postnatal observations also depends on the technique used to quantify Scr [Jaffe colorimetry or enzymatic quantification]. Methods: In an attempt to quantify differences between these techniques, we compared postnatal Scr trends in two consecutive cohorts of extremely low birth weight (ELBW) neonates before and following a switch from uncompensated Jaffe to enzymatic Scr quantification. Postnatal Scr (day 1,2,3,4,5,6,7,8,9,14,21,28,42) in 151 ELBW neonates (uncompensated Jaffe) was compared to 116 more recently admitted ELBW neonates (enzymatic). Results: While clinical characteristics were similar between both cohorts, median postnatal Jaffe Scr values were significantly higher compared to enzymatic quantification (all days, at least p<0.001) throughout postnatal life. While both cohorts displayed a similar trend with an initial increase with a Scr peak on day 3-4 and a subsequent decrease, the difference in within-day median values fluctuated between 11-24 mmol.l(-1). There is no fixed nor relative difference in Scr between both techniques. Conclusions: When using Scr to estimate renal function in ELBW neonates, clinicians should in addition to the postnatal changes and other covariates of renal function, also consider the technique applied. We provide reference values and comparison between both techniques.
Karel Allegaert; Maike Kuppens; Djalila Mekahli; Elena Levtchenko; Florent Vanstapel; Christine Vanhole; John N van den Anker
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-24
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Neonatal Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium.
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