Document Detail

Creatinine kinase kinetics studied by phosphorus-31 nuclear magnetic resonance in a canine model of chronic hypertension-induced cardiac hypertrophy.
MedLine Citation:
PMID:  1530854     Owner:  NLM     Status:  MEDLINE    
To determine whether cardiac hypertrophy secondary to chronic renovascular hypertension is associated with altered in vivo myocardial metabolism, phosphorus-31 nuclear magnetic resonance saturation transfer techniques were used to study creatine kinase (CK) kinetics in six chronically hypertensive dogs with moderate cardiac hypertrophy and eight control dogs. The forward rate constant of CK and the flux of phosphocreatine to adenosine triphosphate were determined in both groups of dogs before and during norepinephrine administration (1 microgram/kg per min), used to increase heart rate x systolic blood pressure (rate-pressure product), cardiac output and oxygen consumption. Baseline and norepinephrine-induced changes in rate-pressure product, cardiac output and oxygen consumption were similar in both groups of dogs, as were baseline forward rate constant and flux of phosphocreatine to adenosine triphosphate. However, the norepinephrine-induced changes in forward rate constant and flux were significantly less in hypertensive than in control dogs (p less than 0.05) even though changes in hemodynamic and functional variables were similar in both groups. These data demonstrate that moderate myocardial hypertrophy is associated with altered CK kinetics, which do not appear to affect the heart's ability for global mechanical recruitment at this stage in the hypertensive process. It is possible that the changes in myocardial enzyme kinetics may contribute to diastolic dysfunction previously reported in this model and may be a precursor for ultimate development of heart failure if hypertension is maintained for prolonged periods.(ABSTRACT TRUNCATED AT 250 WORDS)
M Osbakken; P S Douglas; T Ivanics; D N Zhang; T Van Winkle
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  19     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-02-11     Completed Date:  1992-02-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  223-8     Citation Subset:  AIM; IM    
Department of Medicine (Cardiology), School of Medicine, University of Pennsylvania, Philadelphia 19104.
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MeSH Terms
Adenosine Triphosphate / biosynthesis
Cardiomegaly / etiology,  metabolism*,  ultrasonography
Chronic Disease
Creatine Kinase / metabolism*
Disease Models, Animal*
Epinephrine / pharmacology
Heart / drug effects
Hypertension, Renovascular / complications,  metabolism*,  ultrasonography
Magnetic Resonance Spectroscopy / methods
Myocardium / metabolism
Phosphocreatine / metabolism
Phosphorus Radioisotopes
Grant Support
R01 HL-39208-03/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Phosphorus Radioisotopes; 51-43-4/Epinephrine; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine; EC Kinase
Comment In:
J Am Coll Cardiol. 1992 Jan;19(1):229-31   [PMID:  1530855 ]

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