| Creatinine inhibits D-amino acid oxidase. | |
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MedLine Citation:
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PMID: 12053066 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inhibition of D-amino acid oxidase (DAO) activity by various uremic retention products and guanidino compounds was investigated. Creatinine (CTN) was found to inhibit DAO at a similar concentration in the sera of uremic patients. The inhibition was competitive and the K(i) value was 2.7 mM. Moreover, CTN was shown to interact with flavin adenine dinucleotide (FAD), a coenzyme of DAO. The UV spectral change of FAD bound to DAO was observed in the visible region by addition of CTN. These findings suggest that the increase in serum and tissue CTN concentrations might be responsible, in part, for the increase in D-amino acids in the sera of uremic patients. |
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Authors:
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Y Nohara; J Suzuki; T Kinoshita; M Watanabe |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Nephron Volume: 91 ISSN: 0028-2766 ISO Abbreviation: Nephron Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-06-07 Completed Date: 2003-02-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0331777 Medline TA: Nephron Country: Switzerland |
Other Details:
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Languages: eng Pagination: 281-5 Citation Subset: IM |
Copyright Information:
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Copyright 2002 S. Karger AG, Basel |
Affiliation:
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Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa, Japan. d96003@pharm.teikyo-u.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alanine
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blood Alanine Transaminase / metabolism Creatinine / blood, pharmacology* D-Amino-Acid Oxidase / antagonists & inhibitors*, metabolism* Enzyme Activation / drug effects Flavin-Adenine Dinucleotide / metabolism Humans Serine / blood Uremia / enzymology* |
| Chemical | |
Reg. No./Substance:
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146-14-5/Flavin-Adenine Dinucleotide; 56-41-7/Alanine; 56-45-1/Serine; 60-27-5/Creatinine; EC 1.4.3.3/D-Amino-Acid Oxidase; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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