| Creatinine and glomerular filtration rate: evolution of an accommodation. | |
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MedLine Citation:
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PMID: 17270087 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This brief review examines the history of the use of creatinine as a measure of renal function. While there are more accurate markers of glomerular filtration, creatinine was chosen for convenience. Since the relationship of creatinine to glomerular filtration depends upon a tenuous balance of counterbalancing factors, practitioners should be alert to situations that alter that balance. While the averaging of variations over time helps to avoid some of the problems with diurnal variations in the past, the present-day reliance upon equations based upon a solitary serum value is likely to amplify those problems in clinical situations when the effect of disease, medications, diet and time of day upon that balance are not considered. |
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Authors:
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Charles J Diskin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of clinical biochemistry Volume: 44 ISSN: 0004-5632 ISO Abbreviation: Ann. Clin. Biochem. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-02-02 Completed Date: 2007-06-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0324055 Medline TA: Ann Clin Biochem Country: England |
Other Details:
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Languages: eng Pagination: 16-9 Citation Subset: IM |
Affiliation:
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Hypertension, Nephrology, Dialysis, and Transplantation Clinic, Auburn University, Building 21, 121 N. 20th Street, Opelika, AL 36801, USA. hndt512@bellsouth.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Creatinine
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analysis* Glomerular Filtration Rate / physiology* Humans Kidney Function Tests / methods* Reproducibility of Results |
| Chemical | |
Reg. No./Substance:
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60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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