Document Detail


Creating polyketide diversity through genetic engineering.
MedLine Citation:
PMID:  12456305     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Modular polyketide synthases (PKS) are large multifunctional enzymes that synthesize complex polyketides, a therapeutically important class of natural products. The linear order and composition of catalytic sites that comprise the PKS represent a "code" that determines the identity of the polyketide product. By re-programming the PKS through genetic engineering, it is possible to alter the code in a predictable manner to create specific structural modifications of polyketides and to produce new libraries of these natural products.
Authors:
James T Kealey
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Publication Detail:
Type:  Journal Article; Review     Date:  2003-01-01
Journal Detail:
Title:  Frontiers in bioscience : a journal and virtual library     Volume:  8     ISSN:  1093-4715     ISO Abbreviation:  Front. Biosci.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2002-11-28     Completed Date:  2004-02-02     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9709506     Medline TA:  Front Biosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  c1-13     Citation Subset:  IM    
Affiliation:
Kosan Biosciences, 3832 Bay Center Place, Hayward, CA 94545, USA. kealey@kosan.com
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MeSH Terms
Descriptor/Qualifier:
Carbohydrate Sequence / genetics
Epothilones / chemistry,  genetics
Erythromycin / chemistry,  metabolism
Molecular Structure
Multienzyme Complexes / biosynthesis*,  chemistry,  genetics*,  physiology
Peptides / chemistry,  genetics
Protein Engineering / methods*
Ribosomal Proteins / chemistry,  genetics
Sirolimus / chemistry,  metabolism
Chemical
Reg. No./Substance:
0/Epothilones; 0/Multienzyme Complexes; 0/Peptides; 0/Ribosomal Proteins; 0/desoxyepothilone B; 114-07-8/Erythromycin; 53123-88-9/Sirolimus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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