Document Detail

Creating a bio-hybrid signal transduction pathway: opening a new channel of communication between cells and machines.
MedLine Citation:
PMID:  23154675     Owner:  NLM     Status:  Publisher    
Manipulation of signal transduction pathways presents a viable mechanism to interface cells with electronics. In this work, we present a two-step signal transduction pathway involving cellular and electronic transduction elements. In order to circumvent many of the conventional difficulties encountered when harnessing chemical signalling for the purpose of electronics communication, gaseous nitric oxide (NO) was selected as the signalling molecule. By genetic engineering of the nitric oxide synthase protein eNOS and insertion of light-oxygen-voltage (LOV) domains, we have created a photoactive version of the protein. The novel chimeric eNOS was found to be capable of producing NO in response to excitation by visible light. By coupling these mutant cells to a surface modified platinum electrode, it was possible to convert an optical signal into a chemical one, followed by subsequent conversion of the chemical signal into an electrical output.
Orr Yarkoni; Lynn Donlon; Daniel Frankel
Related Documents :
22517855 - A universal method to produce low-work function electrodes for organic electronics.
3042885 - Fibrous component of yeast mitochondria.
21844595 - Picoscale science and nanoscale engineering by electron microscopy.
24822395 - Silicon nanocrystals doping and surface modification.
21378255 - Influence of unclogging agents on the surface state of enteral feeding tubes.
22889055 - Effect of molecular symmetry on the spectra and dynamics of the intramolecular charge t...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-15
Journal Detail:
Title:  Bioinspiration & biomimetics     Volume:  7     ISSN:  1748-3190     ISO Abbreviation:  Bioinspir Biomim     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101292902     Medline TA:  Bioinspir Biomim     Country:  -    
Other Details:
Languages:  ENG     Pagination:  046017     Citation Subset:  -    
Department of Chemical Engineering, Newcastle University, Merz Court, Newcastle. NE1 7RU, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  VAP-1, a Novel Molecule Linked to Endothelial Damage and Kidney Function in Kidney Allograft Recipie...
Next Document:  Staffing matters-every shift: data from the Military Nursing Outcomes Database can be used to demons...