Document Detail


Creating a bio-hybrid signal transduction pathway: opening a new channel of communication between cells and machines.
MedLine Citation:
PMID:  23154675     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Manipulation of signal transduction pathways presents a viable mechanism to interface cells with electronics. In this work, we present a two-step signal transduction pathway involving cellular and electronic transduction elements. In order to circumvent many of the conventional difficulties encountered when harnessing chemical signalling for the purpose of electronics communication, gaseous nitric oxide (NO) was selected as the signalling molecule. By genetic engineering of the nitric oxide synthase protein eNOS and insertion of light-oxygen-voltage (LOV) domains, we have created a photoactive version of the protein. The novel chimeric eNOS was found to be capable of producing NO in response to excitation by visible light. By coupling these mutant cells to a surface modified platinum electrode, it was possible to convert an optical signal into a chemical one, followed by subsequent conversion of the chemical signal into an electrical output.
Authors:
Orr Yarkoni; Lynn Donlon; Daniel Frankel
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-15
Journal Detail:
Title:  Bioinspiration & biomimetics     Volume:  7     ISSN:  1748-3190     ISO Abbreviation:  Bioinspir Biomim     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101292902     Medline TA:  Bioinspir Biomim     Country:  -    
Other Details:
Languages:  ENG     Pagination:  046017     Citation Subset:  -    
Affiliation:
Department of Chemical Engineering, Newcastle University, Merz Court, Newcastle. NE1 7RU, UK.
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