| Creatine supplementation spares muscle glycogen during high intensity intermittent exercise in rats. | |
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MedLine Citation:
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PMID: 20205834 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The effects of creatine (CR) supplementation on glycogen content are still debatable. Thus, due to the current lack of clarity, we investigated the effects of CR supplementation on muscle glycogen content after high intensity intermittent exercise in rats. METHODS: First, the animals were submitted to a high intensity intermittent maximal swimming exercise protocol to ensure that CR-supplementation was able to delay fatigue (experiment 1). Then, the CR-mediated glycogen sparing effect was examined using a high intensity intermittent sub-maximal exercise test (fixed number of bouts; six bouts of 30-second duration interspersed by two-minute rest interval) (experiment 2). For both experiments, male Wistar rats were given either CR supplementation or placebo (Pl) for 5 days. RESULTS: As expected, CR-supplemented animals were able to exercise for a significant higher number of bouts than Pl. Experiment 2 revealed a higher gastrocnemius glycogen content for the CR vs. the Pl group (33.59%). Additionally, CR animals presented lower blood lactate concentrations throughout the intermittent exercise bouts compared to Pl. No difference was found between groups in soleus glycogen content. CONCLUSION: The major finding of this study is that CR supplementation was able to spare muscle glycogen during a high intensity intermittent exercise in rats. |
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Authors:
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Hamilton Roschel; Bruno Gualano; Marcelo Marquezi; André Costa; Antonio H Lancha |
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Publication Detail:
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Type: Journal Article Date: 2010-01-29 |
Journal Detail:
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Title: Journal of the International Society of Sports Nutrition Volume: 7 ISSN: 1550-2783 ISO Abbreviation: J Int Soc Sports Nutr Publication Date: 2010 |
Date Detail:
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Created Date: 2010-03-08 Completed Date: 2011-07-14 Revised Date: 2011-11-21 |
Medline Journal Info:
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Nlm Unique ID: 101234168 Medline TA: J Int Soc Sports Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 6 Citation Subset: - |
Affiliation:
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School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil. lanchajr@usp.br. |
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