Document Detail

Creatine supplementation enhances maximum voluntary isometric force and endurance capacity in resistance trained men.
MedLine Citation:
PMID:  9715740     Owner:  NLM     Status:  MEDLINE    
The present study examined the hypothesis that creatine (Cr) supplementation can increase the performance of isometric exercise in subjects engaged in a strength training program. Ten male subjects were tested in three experimental trials 7 days apart (days 1, 8 and 15). In each trial the subjects' maximum voluntary force of contraction (MVC) was measured in both legs and isometric endurance capacity at 80, 60, 40 and 20% of MVC of their stronger leg (knee extensor group) was measured with a 4-min rest between contractions. Additionally, the subjects' isometric endurance capacity at 80% of MVC of their weaker leg was measured in 10 repeated bouts interspersed with 2-min rest. A double-blind cross-over design was adopted for administering Cr or placebo. Subjects were randomized into either the Cr-placebo (Group A: days 2-6: 10 g day-1 of Cr; days 9-13: 10 g day-1 of glucose polymers) or the placebo-Cr group (Group B reverse supplementation order). The daily diet was analysed, and urine samples from 24-h collections were subjected to Cr and creatinine analysis. In each subject, approximately 18 g (35%) of Cr was eliminated in the urine during the Cr supplementation period. MVC increased by about 10% (P < 0.01 in the weaker leg, P < 0.05 in the stronger leg) and body mass increased by 1.7 +/- 0.4 kg (2.3%, P < 0.01) and 1.8 +/- 0.3 kg (2.1%, P < 0.01) in groups A and B, respectively, after Cr supplementation, while energy intake and diet composition remained constant throughout the study. The subjects' endurance capacity increased (P < 0.05) in all the bouts after Cr supplementation. Muscle hypertrophy in response to Cr supplementation and weight training may explain the findings of the present study.
C N Maganaris; R J Maughan
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  163     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-11-05     Completed Date:  1998-11-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  279-87     Citation Subset:  IM    
University Medical School, University of Aberdeen, Foresterhill, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Body Weight / drug effects,  physiology
Creatine / pharmacology*,  urine
Cross-Over Studies
Double-Blind Method
Isometric Contraction / drug effects*
Physical Endurance / drug effects*
Physical Fitness / physiology*
Weight Lifting
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Changes in CNTF receptor alpha expression in rat skeletal muscle during the recovery period after hi...
Next Document:  Human sudomotor responses to heating and cooling upper-body skin surfaces: cutaneous thermal sensiti...