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Creatine pre-treatment prevents birth asphyxia-induced injury of the newborn spiny mouse kidney.
MedLine Citation:
PMID:  23174701     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background:Acute kidney injury (AKI) is a major complication for infants following an asphyxic insult at birth. We aimed to determine if kidney structure and function were affected in an animal model of birth asphyxia and if maternal dietary creatine supplementation could provide a energy reserve to the fetal kidney, maintaining cellular respiration during asphyxia and preventing AKI.Methods:Pregnant spiny mice were maintained on normal chow or chow supplemented with creatine from day 20 gestation. On day 38 (term ~39days), pups were delivered by caesarean section or subjected to intrauterine asphyxia. 24 hours (h) after insult, kidneys were collected for histological or molecular analysis. Urine and plasma were also collected for biochemical analysis.Results:AKI was evident 24 h after birth asphyxia, with a higher incidence of shrunken glomeruli (P<0.02), disturbance to tubular arrangement, tubular dilatation, a 2-fold increase (P<0.02) in expression of Ngal (early marker of kidney injury), and decreased expression of the podocyte differentiation marker nephrin. Maternal creatine supplementation prevented the glomerular and tubular abnormalities observed in the kidney at 24 h and the increased expression of Ngal.Conclusion:Maternal creatine supplementation may prove useful in ameliorating kidney injury associated with birth asphyxia.Pediatric Research (2012); doi:10.1038/pr.2012.174.
Authors:
Stacey J Ellery; Zoe Ireland; Michelle M Kett; Rod Snow; David W Walker; Hayley Dickinson
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-22
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
The Ritchie Centre, Monash Institute of Medical Research, Clayton, Australia.
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