| Creatine phosphokinase in ectopic pregnancy revisited: significant diagnostic value of its MB and MM isoenzyme fractions. | |
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MedLine Citation:
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PMID: 16389014 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Although evidence on elevated creatine phosphokinase (CPK) as a tool for the diagnosis of ectopic pregnancy (EP) is rather conflictive, no previous study on CPK isoenzyme levels and their relative ratio was found in the literature. STUDY DESIGN: Forty women with EP, 20 with intrauterine (IU) abortive gestation, and 20 regular pregnant women (controls) were studied. Serum total CPK, CPK-MB, and CPK-MM levels were measured at the time of presentation and 24 hours after surgery. Relative operating characteristic (ROC) curves were plotted. RESULTS: Women with EP had significantly higher CPK concentrations and a significantly decreased CPK-MB relative ratio (CPK-MB%), compared with both women with IU abortive pregnancy and controls. The ROC curves demonstrated a significant discriminatory ability of both increased total CPK and decreased CPK-MB% ratio for the diagnosis of EP. CONCLUSION: Determination of CPK isoenzyme fractions can significantly enhance the diagnostic value of total maternal CPK in the prediction of ectopic pregnancy. |
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Authors:
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Ilias Katsikis; David Rousso; Dimitrios Farmakiotis; Anargyros Kourtis; Evanthia Diamanti-Kandarakis; Vassiliki Zournatzi-Koiou; Dimitrios Panidis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 194 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2006-01-03 Completed Date: 2006-04-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 86-91 Citation Subset: AIM; IM |
Affiliation:
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Division of Endocrinology and Human Reproduction, Second Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Thessaloniki, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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blood,
diagnosis Adolescent Adult Case-Control Studies Creatine Kinase / blood* Creatine Kinase, MB Form / blood* Creatine Kinase, MM Form / blood* Female Humans Osmolar Concentration Predictive Value of Tests Pregnancy / blood Pregnancy, Ectopic / blood*, diagnosis* ROC Curve Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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EC 2.7.3.2/Creatine Kinase; EC 2.7.3.2/Creatine Kinase, MB Form; EC 2.7.3.2/Creatine Kinase, MM Form |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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