Document Detail


Creatine phosphate administration preserves myocardial function in a model of off-pump coronary revascularization.
MedLine Citation:
PMID:  15956929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: Off pump coronary artery bypass grafting (OPCAB) involves, and is occasionally impaired by obligatory regional myocardial ischemia, particularly with the use of proximal coronary in-flow occlusion techniques. Intracoronary shunts do not guarantee absence of distal ischemia given their small inner diameter and the presence of proximal coronary stenosis. Additional adjunctive measures to provide short-term myocardial protection may facilitate OPCAB. High-energy phosphate supplementation with creatine phosphate prior to ischemia may attenuate ischemic dysfunction. METHODS: In a rodent model of a transient coronary occlusion and myocardial ischemia, 36 animals underwent preischemic intravenous infusion of either creatine phosphate or saline, 10 minutes of proximal left anterior descending (LAD) occlusion, and 10 minutes of reperfusion. Rats underwent continuous intracavitary pressure monitoring and cellular ATP levels were quantified using a luciferin/luciferase bioluminescence assay. RESULTS: Within 2 minutes of ischemia onset, creatine phosphate animals exhibited statistically significant greater preservation of myocardial function compared to controls, an augmentation which persisted throughout the duration of ischemia and subsequent reperfusion. Furthermore, significantly greater cellular ATP levels were observed among creatine phosphate treated animals (344+/-55 nMol/g tissue, n=5) compared to control animals (160+/-9 nMol/g tissue, n=5)(p=0.014). CONCLUSIONS: A strategy of intravenous high-energy phosphate administration successfully prevented ischemic ventricular dysfunction in a rodent model of OPCAB.
Authors:
Y J Woo; T J Grand; S Zentko; J E Cohen; V Hsu; P Atluri; M F Berry; M D Taylor; M A Moise; O Fisher; S Kolakowski
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of cardiovascular surgery     Volume:  46     ISSN:  0021-9509     ISO Abbreviation:  J Cardiovasc Surg (Torino)     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-15     Completed Date:  2006-09-19     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0066127     Medline TA:  J Cardiovasc Surg (Torino)     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  297-305     Citation Subset:  IM    
Affiliation:
Division of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania, Philadelphia 19104, USA. wooy@uphs.penn.edu
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / metabolism
Animals
Cardiotonic Agents / administration & dosage*
Coronary Artery Bypass, Off-Pump / methods*
Disease Models, Animal
Infusions, Intravenous
Male
Myocardial Ischemia / metabolism,  physiopathology,  prevention & control*
Myocardium / metabolism
Phosphocreatine / administration & dosage*
Rats
Rats, Wistar
Stroke Volume / drug effects,  physiology
Treatment Outcome
Troponin I / blood
Chemical
Reg. No./Substance:
0/Cardiotonic Agents; 0/Troponin I; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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