Document Detail


Creatine kinase, myosin heavy chains and magnetic resonance imaging after eccentric exercise.
MedLine Citation:
PMID:  11522144     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to examine the relationship between myosin heavy chain (MHC) release as a specific marker of slow-twitch muscle fibre breakdown and magnetic resonance imaging (MRI) of skeletal muscle injury after eccentric exercise. The effects of a single series of 70 high-intensity eccentric contractions of the quadriceps femoris muscle group (single leg) on plasma concentrations of creatine kinase and MHC fragments were assessed in 10 young male sport education trainees before and 1 and 4 days after exercise. To visualize muscle injury, MRI of the loaded thigh was performed before and 4 days after the eccentric exercise. All participants recorded an increase (P < 0.05) in creatine kinase after exercise. In five participants, T2 signal intensity was unchanged post-exercise compared with pre-exercise and MHC plasma concentration was normal; however, they showed an increase (P < 0.05) in creatine kinase after exercise. For the remaining five participants, there was an increase in T2 signal intensity of the loaded vastus intermedius and vastus lateralis. These changes in MRI were accompanied by an increase in MHC plasma concentration (P< 0.01) as well as an increase in creatine kinase (P < 0.01). We suggest that changes in MRI T, signal intensity after muscle damage induced by eccentric exercise are closely related to damage to structurally bound contractile filaments of some muscle fibres. Additionally, MHC plasma release indicates that this damage affects not only fast-twitch fibres but also some slow-twitch fibres.
Authors:
S Sorichter; J Mair; A Koller; E Müller; C Kremser; W Judmaier; C Haid; C Calzolari; B Puschendorf
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of sports sciences     Volume:  19     ISSN:  0264-0414     ISO Abbreviation:  J Sports Sci     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-08-27     Completed Date:  2002-01-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8405364     Medline TA:  J Sports Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  687-91     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Division of Pneumology, University Hospital of Freiburg, Germany. sorichter@med1.ukl.uni-freiburg.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Creatine Kinase / blood*
Exercise / physiology*
Humans
Magnetic Resonance Imaging*
Male
Muscle Contraction / physiology
Muscle Fibers, Slow-Twitch / pathology
Muscle, Skeletal / injuries,  metabolism*,  radiography
Myosin Heavy Chains / blood*
Chemical
Reg. No./Substance:
0/Myosin Heavy Chains; EC 2.7.3.2/Creatine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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