Document Detail

Creatine kinase monitoring in sport medicine.
MedLine Citation:
PMID:  17569697     Owner:  NLM     Status:  MEDLINE    
AREAS THAT ARE CONTROVERSIAL: Some authors, studying subjects with high levels of CK at rest, observed that, years later, subjects developed muscle weakness and suggested that early myopathy may be asymptomatic. Others demonstrated that, in most of these patients, hyperCKemia probably does not imply disease. In many instances, the diagnosis is not formulated following routine examination with the patients at rest, as symptoms become manifest only after exercise. Some authors think that strength training seems to be safe for patients with myopathy, even though the evidence for routine exercise prescription is still insufficient. Others believe that, in these conditions, intense prolonged exercise may produce negative effects, as it does not induce the physiological muscle adaptations to physical training given the continuous loss of muscle proteins.
GROWING POINTS: High CK serum levels in athletes following absolute rest and without any further predisposing factors should prompt a full diagnostic workup with special regards to signs of muscle weakness or other simple signs that, in both athletes and sedentary subjects, are not always promptly evident. These signs may indicate subclinical muscle disease, which training loads may evidence through the onset of profound fatigue. It is probably safe to counsel athletes with suspected myopathy to continue to undertake physical activity at a lower intensity, so as to prevent muscle damage from high intensity exercise and allow ample recovery to favour adequate recovery.
AREAS TIMELY FOR DEVELOPING RESEARCH: CK values show great variability among individuals. Some athletes are low responders to physical training, with chronically low CK serum levels. Some athletes are high responders, with higher values of enzyme: the relationship among level of training, muscle size, fibre type and CK release after exercise should be investigated further. In addition, more details about hyperCKemia could come from the evaluation of the kinetics of CK after stress in healthy athletes with high levels of CK due to exercise, comparing the results with the ones obtained from athletes with persistent hyperCKemia at rest. Finally, it would be important to quantify the type of exercise more suited to athletes with myopathy and the intensity of exercise not dangerous for the progression of the pathology.
Paola Brancaccio; Nicola Maffulli; Francesco Mario Limongelli
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-06-14
Journal Detail:
Title:  British medical bulletin     Volume:  81-82     ISSN:  0007-1420     ISO Abbreviation:  Br. Med. Bull.     Publication Date:  2007  
Date Detail:
Created Date:  2007-06-29     Completed Date:  2007-12-17     Revised Date:  2013-07-15    
Medline Journal Info:
Nlm Unique ID:  0376542     Medline TA:  Br Med Bull     Country:  England    
Other Details:
Languages:  eng     Pagination:  209-30     Citation Subset:  IM    
Department of Experimental Medicine-Sport Medicine, Centre of Excellence of Cardiovascular Disease, Seconda Università di Napoli, Napoli, Italy.
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MeSH Terms
Biological Markers / blood
Creatine Kinase / blood*
Exercise / physiology*
Muscle, Skeletal / enzymology*,  physiology
Muscular Diseases / prevention & control
Sports / physiology*
Reg. No./Substance:
0/Biological Markers; EC Kinase

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