| Creatine kinase and its CK-MB isoenzyme: the conventional marker for the diagnosis of acute myocardial infarction. | |
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MedLine Citation:
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PMID: 9950395 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Biochemical markers are commonly used for detection, diagnosis, and management of various diseases. Creatine kinase (CK) is an enzyme found in most tissues, and is the best known marker for the identification of acute myocardial infarction (AMI). We review the most common techniques used to quantify creatine kinase and its cardiac specific fraction, CK-MB. Electrophoresis, immunoinhibition, monoclonal immunoassay, and CK-MB isoform assays are considered for efficacy, sensitivity and specificity, and timeliness in the setting of acute non-traumatic chest pain. Limitations of the various techniques for identifying AMI are identified. Current recommendations for CK-MB panels, including combinations with other cardiac markers, are included. |
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Authors:
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D J Robinson; R H Christenson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of emergency medicine Volume: 17 ISSN: 0736-4679 ISO Abbreviation: J Emerg Med Publication Date: 1999 Jan-Feb |
Date Detail:
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Created Date: 1999-04-13 Completed Date: 1999-04-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8412174 Medline TA: J Emerg Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 95-104 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of Maryland School of Medicine, Baltimore 21201, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Chest Pain / diagnosis, etiology Clinical Enzyme Tests* Creatine Kinase / blood* Electrophoresis Humans Isoenzymes Myocardial Infarction / diagnosis* Sensitivity and Specificity Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Isoenzymes; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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