Document Detail

Creatine kinase isoenzymes in severe head injury.
MedLine Citation:
PMID:  6834117     Owner:  NLM     Status:  MEDLINE    
Brain-type creatine kinase (CK) isoenzyme (CK-BB) was found in the ventricular cerebrospinal fluid (CSF) and the serum in a series of 35 patients within 13 hours following severe head injury. There was a good correlation between total CK and CK-BB activities in CSF only. The values found in the CSF appear to be a quantitative index of brain dysfunction at admission, and did not correlate with intracranial pressure activity. High levels of CK-BB in the CSF correlated with a poor outcome, and thus offer a reliable criterion for the assessment of the severity of head injury.
P Hans; J D Born; J P Chapelle; G Milbouw
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  58     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  1983 May 
Date Detail:
Created Date:  1983-05-27     Completed Date:  1983-05-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  689-92     Citation Subset:  AIM; IM    
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MeSH Terms
Brain Injuries / enzymology*
Child, Preschool
Coma / enzymology
Creatine Kinase / blood,  cerebrospinal fluid*
Intracranial Pressure
Middle Aged
Reg. No./Substance:
0/Isoenzymes; EC Kinase

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