| Creatine kinase isoenzyme profiles after exercise in the rat: sex-linked differences in leakage of CK-MM. | |
| | |
MedLine Citation:
|
PMID: 3174399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Changes in creatine kinase (CK) activity and CK isoenzyme profiles in plasma after exercise were studied in rats in order to establish the source of the exercise-induced rise in CK activity. Male and female rats ran on a treadmill for 2 h and blood samples, taken before and after exercise, were assayed for total CK, CK isoenzymes and aminoaspartate transaminase (AST) activity. These enzymes were also assayed in homogenates of liver and several muscles. We found that the isoenzyme composition of liver, plasma and muscle did not differ between the sexes. However, the exercise-induced CK and AST responses did differ: CK and AST increased after exercise in males (101% and 15% resp.), but much less in females (47% and 1%). Although the isoenzyme profiles in rest did not differ, significant differences were observed after running: in males CK-MM increased with 678%, but females only showed a 114% increase. In contrast, CK-BB showed a small increase that was about the same for both sexes (males 41%, females 35%). We conclude that both males and females show a small and similar increase in CK-BB activity after exercise, and that a large release of CK-MM from skeletal muscle, observed only in males, accounts for sex-linked differences reported earlier. |
| | |
Authors:
|
G J Amelink; H H Kamp; P R Bär |
Related Documents
:
|
689019 - Changes in serum creatine kinase and hexose phosphate isomerase activity with exercise ... 14574579 - Short-term creatine supplementation does not improve muscle activation or sprint perfor... 7433939 - Assessment of cerebral damage during open-heart surgery. a new experimental model. 19697999 - Effects of low-level laser irradiation on rat skeletal muscle injury after eccentric ex... 17724609 - Non-uniform changes in magnetic resonance measurements of the semitendinosus muscle fol... 21109459 - Exaggerated increase in cardiac output during exercise in patients with peripheral high... 7061689 - Ultrastructural and biochemical characterization of human brown adipose tissue in pheoc... 9132209 - Physiological responses of wheelchair athletes at percentages of top speed. 15582629 - Simulation of pulmonary ventilation and its control by negative feedback. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Pflügers Archiv : European journal of physiology Volume: 412 ISSN: 0031-6768 ISO Abbreviation: Pflugers Arch. Publication Date: 1988 Sep |
Date Detail:
|
Created Date: 1988-11-22 Completed Date: 1988-11-22 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0154720 Medline TA: Pflugers Arch Country: GERMANY, WEST |
Other Details:
|
Languages: eng Pagination: 417-21 Citation Subset: IM; S |
Affiliation:
|
Research Laboratory Neurology, University of Utrecht, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Creatine Kinase / blood*, metabolism Female Isoenzymes Liver / enzymology Male Muscles / enzymology Physical Exertion* Rats Rats, Inbred Strains Sex Factors |
| Chemical | |
Reg. No./Substance:
|
0/Isoenzymes; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Feline left ventricular oxygen consumption is not affected by volume expansion, ejection or redevelo...
Next Document: Potassium transport in epithelial cells isolated from small intestine of the chicken.