Document Detail


Creatine kinase isoenzyme BB in the cerebrospinal fluid of patients with acute neurological diseases.
MedLine Citation:
PMID:  2299298     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to predict the outcome of patients with acute neurological symptoms at discharge, the concentration of creatine kinase isoenzyme BB (CK-BB) was determined by radioimmunoassay in the cerebrospinal fluid (CSF) of 115 consecutive patients. On admission and over the next 3 days the concentration of CK-BB was significantly increased in patients with brain death and other neurological sequelae compared with those with favourable outcome. There was a variation in time in concentrations of CK-BB between diseases causing neurological sequelae. Thus, cerebrovascular haemorrhages caused highest concentrations on admission, but cerebral ischaemia due to cardiac arrest caused highest concentrations 3 days after admission. On admission the CK-BB measurements were highly specific with high predictive value of positive result when distinguishing patients with brain death and other neurological sequelae from those without complications at discharge. However, when distinguishing patients with brain death from those with other neurological sequelae, the test was most specific and had highest predictive value of a positive result 3 days after admission.
Authors:
A Bödvarsson; L Franzson; H Briem
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of internal medicine     Volume:  227     ISSN:  0954-6820     ISO Abbreviation:  J. Intern. Med.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-03-07     Completed Date:  1990-03-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  5-9     Citation Subset:  IM    
Affiliation:
Department of Medicine, Reykjavik City Hospital, Iceland.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Cerebral Hemorrhage / enzymology
Cerebrovascular Disorders / enzymology
Creatine Kinase / cerebrospinal fluid*
Humans
Isoenzymes / cerebrospinal fluid
Middle Aged
Nervous System Diseases / diagnosis,  enzymology*
Time Factors
Chemical
Reg. No./Substance:
0/Isoenzymes; EC 2.7.3.2/Creatine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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