Document Detail


Creatine kinase in epithelium of the inner ear.
MedLine Citation:
PMID:  1313059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epithelium of the inner ear in the gerbil and mouse was examined immunocytochemically for presence of creatine kinase (CK). Marginal cells of the cochlear stria vascularis and dark cells and transitional cells of the vestibular system were found to contain an abundance of the MM isozyme (MM-CK). CK in these cells concurs with that which is coupled to Na,K-ATPase in other cells and is considered to supply ATP for the Na,K-ATPase that mediates the high KCl of endolymph. Inner hair cells revealed content of the BB isozyme and in this respect resembled the energy-transducing photoreceptor cells in retina. In addition, outer phalangeal (Deiters') cells stained for both MM- and BB-CK whereas inner phalangeal cells evidenced content of only the BB isozyme. Immunolocalization of CK appeared similar in mouse and gerbil inner ear. Specificity of the staining was affirmed by observations in agreement with those reported for CK in various cell types and by staining with antisera from more than one source.
Authors:
S S Spicer; B A Schulte
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society     Volume:  40     ISSN:  0022-1554     ISO Abbreviation:  J. Histochem. Cytochem.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-04-27     Completed Date:  1992-04-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9815334     Medline TA:  J Histochem Cytochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  185-92     Citation Subset:  IM    
Affiliation:
Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston 29425.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cochlea / cytology,  enzymology*
Creatine Kinase / analysis*
Ear, Inner / cytology,  enzymology*
Epithelial Cells
Epithelium / enzymology
Gerbillinae
Hair Cells, Auditory, Inner / cytology,  enzymology
Immunohistochemistry
Isoenzymes
Mice
Mice, Inbred C57BL
Muscle, Smooth / cytology,  enzymology
Sodium-Potassium-Exchanging ATPase / analysis
Grant Support
ID/Acronym/Agency:
P50 DC00422/DC/NIDCD NIH HHS; R01 DC00713/DC/NIDCD NIH HHS
Chemical
Reg. No./Substance:
0/Isoenzymes; EC 2.7.3.2/Creatine Kinase; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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