Document Detail


Creatine kinase and creatine kinase isoenzymes as a marker of uterine activity.
MedLine Citation:
PMID:  1418156     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Creatine kinase (CK) and CK isoenzymes are known to fluctuate in labor. Reliable information about the longitudinal changes of CK and CK isoenzymes during labor is sparse. Nevertheless, they have been used to direct care in women with cardiopulmonary disease and preterm labor requiring tocolysis. This study evaluated fluctuations of CK and its isoenzymes longitudinally across labor in 49 women. Blood samples were obtained at 33 to 34 weeks' estimated gestational age, on admission in labor at 3 cm or less dilation, 8 cm to complete dilation, and postpartum in the recovery room. Specimens were analyzed for total CK, CK-MM, CK-MB, and CK-BB activity. CK levels increased for all peripartum patients (p < 0.001). CK activity at 3 cm was greater than at 34 weeks (p < 0.01). Furthermore, the early rise in CK activity was greater in those in active labor compared with those who required oxytocin stimulation (p < 0.001). CK values at 8 cm and postdelivery (mean IU/liter) were often above nonpregnant norms. The early rise of CK in spontaneously laboring patients versus those requiring oxytocin augmentation may represent a difference in uterine activity. Nonpregnant normative data for CK is not appropriate when assessing cardiovascular side effects of betamimetic therapy.
Authors:
A J Satin; G D Hankins; W R Patterson; R T Scott
Related Documents :
9527946 - Meconium aspiration syndrome: importance of the monitoring of labor.
16139416 - When to induce labor for post-term? a study of induction at 41 weeks versus 42 weeks.
11576566 - Active phase labor arrest: revisiting the 2-hour minimum.
11573116 - A comparison of spontaneous labor with induced vaginal tablets prostaglandin e2 in gran...
8587866 - Early amniocentesis and fetal nuchal translucency in women requesting karyotyping for a...
10417506 - Serum concentrations of tramadol enantiomers during patient-controlled analgesia.
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of perinatology     Volume:  9     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:    1992 Sep-Nov
Date Detail:
Created Date:  1992-12-16     Completed Date:  1992-12-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  456-9     Citation Subset:  IM    
Affiliation:
Department of Obstetrics & Gynecology, Wilford Hall USAF Medical Center, Lackland AFB, Texas.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Biological Markers / blood
Creatine Kinase / blood*
Female
Humans
Isoenzymes
Labor, Induced*
Labor, Obstetric / physiology*
Longitudinal Studies
Postpartum Period / physiology*
Pregnancy
Uterus / physiology*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Isoenzymes; EC 2.7.3.2/Creatine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Detection of intra-amniotic infection by gas-liquid chromatography.
Next Document:  Is there a "dominant twin" in utero?