Document Detail

Creatine kinase and creatine kinase isoenzymes as a marker of uterine activity.
MedLine Citation:
PMID:  1418156     Owner:  NLM     Status:  MEDLINE    
Creatine kinase (CK) and CK isoenzymes are known to fluctuate in labor. Reliable information about the longitudinal changes of CK and CK isoenzymes during labor is sparse. Nevertheless, they have been used to direct care in women with cardiopulmonary disease and preterm labor requiring tocolysis. This study evaluated fluctuations of CK and its isoenzymes longitudinally across labor in 49 women. Blood samples were obtained at 33 to 34 weeks' estimated gestational age, on admission in labor at 3 cm or less dilation, 8 cm to complete dilation, and postpartum in the recovery room. Specimens were analyzed for total CK, CK-MM, CK-MB, and CK-BB activity. CK levels increased for all peripartum patients (p < 0.001). CK activity at 3 cm was greater than at 34 weeks (p < 0.01). Furthermore, the early rise in CK activity was greater in those in active labor compared with those who required oxytocin stimulation (p < 0.001). CK values at 8 cm and postdelivery (mean IU/liter) were often above nonpregnant norms. The early rise of CK in spontaneously laboring patients versus those requiring oxytocin augmentation may represent a difference in uterine activity. Nonpregnant normative data for CK is not appropriate when assessing cardiovascular side effects of betamimetic therapy.
A J Satin; G D Hankins; W R Patterson; R T Scott
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of perinatology     Volume:  9     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:    1992 Sep-Nov
Date Detail:
Created Date:  1992-12-16     Completed Date:  1992-12-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  456-9     Citation Subset:  IM    
Department of Obstetrics & Gynecology, Wilford Hall USAF Medical Center, Lackland AFB, Texas.
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MeSH Terms
Biological Markers / blood
Creatine Kinase / blood*
Labor, Induced*
Labor, Obstetric / physiology*
Longitudinal Studies
Postpartum Period / physiology*
Uterus / physiology*
Reg. No./Substance:
0/Biological Markers; 0/Isoenzymes; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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