Document Detail

Creatine kinase and aldolase in serum: abnormality common to acute psychoses.
MedLine Citation:
PMID:  5644267     Owner:  NLM     Status:  MEDLINE    
Activity of creatine kinase and aldolase in serum increased in 14 of 16 patients with recent onset of a psychotic reaction, and in five of six patients treated with psychotomimetic drugs. There was either no increase of these enzymes or a slight increase in severely agitated (or depressed) non-psychotic hospitalized patients and chronic psychotic patients. The increase of the enzymes preceded the onset of the acute psychotic symptoms in at least three cases, was highest during the first 2 weeks of a psychotic episode, and sometimes recurred throughout the illness, particularly at times of stress. The creatine kinase in the serum is primarily of the muscle type.
H Meltzer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  159     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1968 Mar 
Date Detail:
Created Date:  1968-05-23     Completed Date:  1968-05-23     Revised Date:  2011-12-02    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1368-70     Citation Subset:  IM    
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MeSH Terms
Bipolar Disorder / blood*
Catatonia / blood*
Clinical Enzyme Tests
Creatine Kinase / blood*
Depression / blood
Fructose-Bisphosphate Aldolase / blood*
Hallucinogens / therapeutic use
Lysergic Acid Diethylamide / therapeutic use
Mental Disorders / blood
Models, Psychological
Muscles / enzymology
Paranoid Disorders / blood*
Personality Disorders / blood
Psychotic Disorders / blood*,  diagnosis
Schizophrenia / blood*
Tryptamines / therapeutic use
Reg. No./Substance:
0/Hallucinogens; 0/Tryptamines; 50-37-3/Lysergic Acid Diethylamide; EC Kinase; EC Aldolase

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