Document Detail

Creatine kinase activity and blood pressure in a normal population: the Tromsø study.
MedLine Citation:
PMID:  21063205     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: In the vast majority of cases the cause for hypertension is not known. On the basis of observations from black and multiethnic populations, it has been hypothesized that a genetically high tissue creatine kinase activity may be an independent factor responsible for primary hypertension. If the relation between creatine kinase and blood pressure is causal, it is reasonable to believe that it will be independent of ethnicity and present in different populations. In this cross-sectional study, we examined whether creatine kinase was associated with blood pressure in a large Caucasian normal population.
METHODS AND RESULTS: Data on creatine kinase and blood pressure were analyzed in a random sample of 12 776 men and women (65% of those eligible), aged 30-87 years from a normal population in the municipality of Tromsø, Norway. We used linear regression to model the association between creatine kinase and blood pressure. Creatine kinase was independently associated with blood pressure. A one unit increase in log CK was associated with a 3.3 (95% CI 1.4-5.2) mmHg increase in systolic blood pressure and a 1.3 (95% CI 0.3-2.3) mmHg increase in diastolic blood pressure, after adjustment for age, sex, body mass index, s-glucose, s-creatinine, physical activity and alcohol consumption. The creatine kinase effect on blood pressure was independent of antihypertensive medication, and no difference in creatine kinase level was found between those with controlled and uncontrolled hypertension (geometric mean 101 vs. 104 IU/l, P = 0.1).
CONCLUSION: Creatine kinase was associated with blood pressure in this population.
Stein H Johnsen; Hallvard Lilleng; Tom Wilsgaard; Svein I Bekkelund
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  29     ISSN:  1473-5598     ISO Abbreviation:  J. Hypertens.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-16     Completed Date:  2011-04-25     Revised Date:  2011-05-24    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  36-42     Citation Subset:  IM    
Department of Neurology and Clinical Neurophysiology, University Hospital of North Norway, Tromsø, Norway.
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MeSH Terms
Aged, 80 and over
Blood Pressure*
Creatine Kinase / metabolism*
Cross-Sectional Studies
Middle Aged
Population Surveillance*
Reg. No./Substance:
EC Kinase
Comment In:
J Hypertens. 2011 May;29(5):1019; author reply 1019-20   [PMID:  21475048 ]

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