Document Detail

Creatine kinase BB isozyme in the blood during open heart surgery--comparison with creatine kinase MB and MM isozymes.
MedLine Citation:
PMID:  2654440     Owner:  NLM     Status:  MEDLINE    
By using a recently developed highly sensitive enzyme immunoassay method, concentrations of the 3 forms of cytoplasmic creatine kinases (CK-BB, CK-MB and CK-MM) were determined in blood samples serially taken from 18 patients who received mitral valve replacement. Blood CK-BB levels, 0.64 +/- 0.32 ng/ml at the beginning of anesthesia, rose sharply after reperfusion reaching the peak level (23.3 +/- 7.56 ng/ml) 2 hours after reperfusion, and then fell rapidly. The response of CK-BB in blood was rapider and more sensitive than that of CK-MB or CK-MM. The CK-BB concentrations were significantly higher in coronary sinus samples than in arterial samples. These results suggest that the major portion of elevated blood CK-BB level in the early phase after reperfusion are derived from the heart muscle.
A Usui; K Kato; T Abe; M Murase; M Tanaka; E Takeuchi
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  53     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-06-22     Completed Date:  1989-06-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  95-100     Citation Subset:  IM    
Department of Thoracic Surgery, Nagoya University School of Medicine, Japan.
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MeSH Terms
Cardiopulmonary Bypass*
Creatine Kinase / blood*,  urine
Heart Valve Prosthesis
Immunoenzyme Techniques
Intraoperative Period
Mitral Valve / surgery
Myocardial Reperfusion
Reg. No./Substance:
0/Isoenzymes; EC Kinase

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