Document Detail

Creatine determinations as an early marker for the diagnosis of acute myocardial infarction.
MedLine Citation:
PMID:  3214119     Owner:  NLM     Status:  MEDLINE    
In the acute phase of acute myocardial infarction (3-8 h after onset of symptoms) an early transient increase in the creatine concentration of serum, saliva, and especially of urine can be observed. Due to the renal threshold, urine values give a much better discrimination between infarction patients and controls than do serum determination. In some patients secondary peaks of serum and urine creatine concentrations can be seen about 24-36 h after hospital admission. Intramuscular injections of 5.0 mL of a saline solution and muscular trauma interfere with the test, but with angina pectoris interference is absent or limited. Creatine leakage from myocardium is insufficient to explain the observed creatinuria in infarctions, and intact extra-cardiac tissues are believed to be involved in creatine release.
J Delanghe; M De Buyzere; I De Scheerder; D Vogelaers; J Vandenbogaerde; A M Van den Abeele; P Gheeraert; R Wieme
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of clinical biochemistry     Volume:  25 ( Pt 4)     ISSN:  0004-5632     ISO Abbreviation:  Ann. Clin. Biochem.     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1989-02-15     Completed Date:  1989-02-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0324055     Medline TA:  Ann Clin Biochem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  383-8     Citation Subset:  IM    
Department of Clinical Biology, Akademisch Ziekenhuis, Ghent, Belgium.
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MeSH Terms
Aged, 80 and over
Angina Pectoris / blood,  urine
Creatine / analysis*,  blood,  urine
Injections, Intramuscular
Middle Aged
Muscles / analysis
Myocardial Infarction / blood,  diagnosis*,  urine
Myocardium / analysis
Reference Values
Sodium Chloride / administration & dosage
Reg. No./Substance:
57-00-1/Creatine; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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