Document Detail


Craving for alcohol and food during treatment for alcohol dependence: modulation by T allele of 1519T>C GABAAalpha6.
MedLine Citation:
PMID:  18616664     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Craving for alcohol and food has been studied in association with alcohol dependence and eating disorders, respectively. One subclass of the gamma-aminobutyric acid (GABA) receptor, 1519T>C GABA(A)alpha6 has been reported to be associated with both alcohol dependence and weight gain. In this study, we hypothesized that patients being treated for alcohol dependence would report decreased craving for alcohol, but an increased craving for food during a 4-week treatment period. We further hypothesized that the T allele of the 1519T>C GABA(A)alpha6 gene would modulate the extent of changes in craving for alcohol and food. METHODS: This study included 98 male inpatients being treated for alcohol dependence. A 7-point visual analog scale was applied to evaluate relative levels of alcohol and food craving at baseline and again 4 weeks later. Body weight was also checked at the same periods. Genotyping of the 1519T>C SNP in GABA(A)alpha6 was carried out by restriction fragment length polymorphism. RESULTS: There were significant changes in craving for alcohol and food in all patients with alcohol dependence. During the treatment period, body weight increased in all patients with alcohol dependence. Changes in alcohol and food craving in T-allele carriers (CT + TT) of 1519T>C GABA(A)alpha6 were greater than those observed in CC homozygotes. In T-allele carriers, body weight significantly increased and the changes in weight showed a negative correlation with the change in the craving for alcohol and a positive correlation with the changes in craving for food. DISCUSSION: The current results suggest that in T-allele carriers the change in craving for alcohol during treatment for alcohol dependence is negatively associated with changes in craving for food. The T allele of the 1519T>C GABA(A)alpha6 gene may be one of the modulating factors associated with changes in craving for alcohol and food during treatment of patients with alcohol dependence.
Authors:
Doug Hyun Han; Nicholas Bolo; Melissa A Daniels; In Kyoon Lyoo; Kyung Joon Min; Chang Hyun Kim; Perry F Renshaw
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-09
Journal Detail:
Title:  Alcoholism, clinical and experimental research     Volume:  32     ISSN:  1530-0277     ISO Abbreviation:  Alcohol. Clin. Exp. Res.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-10-08     Completed Date:  2008-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7707242     Medline TA:  Alcohol Clin Exp Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1593-9     Citation Subset:  IM    
Affiliation:
Brain Imaging Center, McLean Hospital, Harvard Medical University, Belmont, Massachusetts 02478, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcohol Drinking / genetics*
Alcoholism / genetics*,  therapy
Alleles*
Body Weight
Case-Control Studies
Eating / genetics*
Genotype
Homozygote
Humans
Male
Middle Aged
Pain Measurement
Polymorphism, Single Nucleotide / genetics
Receptors, GABA-A / genetics*
Chemical
Reg. No./Substance:
0/Receptors, GABA-A; 0/alpha6 subunit, GABA-A receptor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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