| Crashing waves of destruction: the cell cycle and APC(Cdh1) regulation of SCF(Skp2). | |
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MedLine Citation:
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PMID: 15093536 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Coordination of events required for cell cycle progression is orchestrated in large part by the ubiquitin (Ub)-mediated destruction of key regulatory proteins such as cyclins and their inhibitors. Until now, the G1/S and mitotic phases of the cell cycle were thought to be controlled by discrete families of multisubunit Ub-ligases: SCF ligases controlled the G1 to S transition, whereas APC ligases controlled the onset and exit from mitosis. New work, published in the March 11 issue of Nature, challenges this concept by revealing that an essential function of APC is to limit SCF activity during the G1 phase of the cell cycle. |
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Authors:
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John F Kurland; William P Tansey |
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Publication Detail:
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Type: Editorial |
Journal Detail:
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Title: Cancer cell Volume: 5 ISSN: 1535-6108 ISO Abbreviation: Cancer Cell Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-04-19 Completed Date: 2004-06-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 101130617 Medline TA: Cancer Cell Country: United States |
Other Details:
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Languages: eng Pagination: 305-6 Citation Subset: IM |
Affiliation:
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Cold Spring Harbor Laboratory, 1 Bungtown Road, P.O. Box 100, Cold Spring Harbor, NY 11724, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle / physiology* Humans S-Phase Kinase-Associated Proteins / metabolism* Ubiquitin-Protein Ligase Complexes / physiology* Ubiquitin-Protein Ligases / physiology* |
| Chemical | |
Reg. No./Substance:
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0/S-Phase Kinase-Associated Proteins; EC 6.3.2.19/Ubiquitin-Protein Ligase Complexes; EC 6.3.2.19/Ubiquitin-Protein Ligases; EC 6.3.2.19/anaphase-promoting complex |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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