Document Detail

Craniopharyngioma: a case report and comparative galectin histochemical analysis.
MedLine Citation:
PMID:  12495217     Owner:  NLM     Status:  MEDLINE    
Craniopharyngioma is a rare benign tumour originating from Rathke's pouch. This paper reports a tumour case studied with a set of markers defining protein-carbohydrate recognition. Expression of endogenous lectins and their reactive glycoligands is under differentiation-dependent control in many cell types. These parameters can be related to the degree of cell differentiation in tumours. Therefore, the expression patterns of endogenous lectins, namely galectins-1, -3, and -7, in the craniopharyngioma case were determined. Galectins-1 and -3 were also used to reveal glycoconjugates in cells and extracellular matrices, an approach that has heretofore relied largely on plant lectins. The staining pattern of craniopharyngioma is compared with that of two other types of ectodermally derived tumours, namely basal and squamous cell carcinomas. Clusters of polygonal and flattened cells with morphological characteristics of differentiated cells in the craniopharyngioma and the majority of poorly differentiated cells in squamous cell carcinomas were reactive with galectin-3. No binding of this probe was observed in cells of basal cell carcinomas and the majority of craniopharyngioma cells. In view of the lack of accessible binding in the basal layer of normal squamous epithelia where proliferative cells (including stem cells) are located, galectin-3 binding could be used to distinguish basal from suprabasal cells of squamous epithelial cells.
Jan Plzák; Pavel Haninec; Karel Smetana; Zuzana Holíková; Sabine André; Ichiro Kuwabara; Fu-Tong Liu; Hans-Joachim Gabius
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Histochemical journal     Volume:  34     ISSN:  0018-2214     ISO Abbreviation:  Histochem. J.     Publication Date:    2002 Mar-Apr
Date Detail:
Created Date:  2002-12-23     Completed Date:  2003-05-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0163161     Medline TA:  Histochem J     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  117-22     Citation Subset:  IM    
1st Faculty of Medicine, Institute of Anatomy, Charles University, Prague, Czech Republic.
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MeSH Terms
Antibodies, Monoclonal / diagnostic use
Binding Sites
Carcinoma, Squamous Cell / metabolism,  pathology
Cell Differentiation / physiology
Craniopharyngioma / metabolism*,  pathology*
Epithelium / metabolism,  pathology
Galectins / metabolism*
Keratins / metabolism
Microscopy, Fluorescence
Neoplasms, Basal Cell / metabolism,  pathology
Pituitary Neoplasms / metabolism*,  pathology*
Polysaccharides / metabolism
Tumor Markers, Biological
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Epitopes; 0/Galectins; 0/Lectins; 0/Polysaccharides; 0/Tumor Markers, Biological; 68238-35-7/Keratins

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