Document Detail


Craniofacial and central nervous system malformations induced by triamcinolone acetonide in nonhuman primates: II. Craniofacial pathogenesis.
MedLine Citation:
PMID:  6635997     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study further defines the craniofacial malformations induced by triamcinolone acetonide in the rhesus monkey. Ten timed-mated pregnant rhesus monkeys (Macaca mulatta) received intramuscular injections of 10 mg/kg TAC on days 23, 25, 27, 29, and 31 of gestation. Results of previous experiments with rhesus and bonnet monkeys and baboons indicated that specific craniofacial and brain malformations could be induced with TAC during this period of pregnancy (Hendrickx et al., '80). Stage-matched TAC-treated and control embryos (stages 17-18 and 22) and age-matched TAC-treated and control fetuses (50, 60, and 70 days gestation) were removed by hysterotomy. Stage 17-18 TAC embryos appeared grossly normal but histologic evaluation revealed a shortened anlage of the posterior cranial base. Stage 22 TAC embryos and all TAC fetuses exhibited craniofacial dysmorphia and encephalocele. The developing sphenoid was the earliest affected and most severely malformed bone. Its defects included reduced anterioposterior and transverse dimensions, reduced orbitosphenoid and alisphenoid, abnormal pituitary fossa, and reduced dorsum and tuberculum sellae. In addition, shortening of the posterior cranial base and decreased cranial base angle was a consistent finding in the treated embryos and fetuses. Decreased ossification and remodeling in the facial bones and abnormal position due to the malformed sphenoid occurred.
Authors:
R M Parker; A G Hendrickx
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Teratology     Volume:  28     ISSN:  0040-3709     ISO Abbreviation:  Teratology     Publication Date:  1983 Aug 
Date Detail:
Created Date:  1983-12-20     Completed Date:  1983-12-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0153257     Medline TA:  Teratology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  35-44     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Central Nervous System / abnormalities*,  drug effects,  embryology
Facial Bones / abnormalities*,  drug effects,  embryology
Female
Fetus / drug effects
Gestational Age
Macaca mulatta
Pregnancy
Skull / abnormalities*,  drug effects,  embryology
Teratogens*
Triamcinolone Acetonide / toxicity*
Grant Support
ID/Acronym/Agency:
HD08658/HD/NICHD NIH HHS; RR00169/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Teratogens; 76-25-5/Triamcinolone Acetonide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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