Document Detail

Craniofacial abnormalities in twins at tygerberg hospital, craniofacial unit.
MedLine Citation:
PMID:  15699669     Owner:  NLM     Status:  MEDLINE    
There is no article in the literature correlating only craniofacial abnormalities in twins. Since 1985 the Tygerberg Craniofacial Unit has treated nine pairs of twins. In this retrospective study, the authors correlate the craniofacial and systemic anomalies with the specific twin type. BACKGROUND: The frequency of human twinning varies from 1 in 30 to 1 in 150 pregnancies. These can be monozygotic (MZ) or dizygotic (DZ). Monozygotic or identical twins occur when a single ovum is fertilized, so the twins possess an identical set of nuclear genes. DZ twins result from the fertilization of two separate ova. FINDINGS: Of the nine sets of twins, six were MZ (identical) and three DZ. Twelve patients presented with craniofacial abnormalities (CFA), which ranged from deformational plagiocephaly, scaphocephaly, trigonocephaly, to frontonasal dysplasia. Craniosynostosis was the most common CFA. Associated abnormalities included facial, limb, and cardiac defects. CONCLUSION: Twins with CFA are rare. The authors found that MZ twins are affected more and are more likely to have both siblings affected. DZ twins are affected less and are unlikely to have a co-twin affected.
Wayne George Kleintjes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of craniofacial surgery     Volume:  16     ISSN:  1049-2275     ISO Abbreviation:  J Craniofac Surg     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-02-08     Completed Date:  2005-03-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9010410     Medline TA:  J Craniofac Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  169-71     Citation Subset:  D    
Plastic and Reconstructive Surgery, Tygerberg Hospital, Cape Town, South Africa, 7505.
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MeSH Terms
Abnormalities, Multiple / genetics
Craniofacial Abnormalities / genetics*
Craniosynostoses / genetics
Diseases in Twins*
Frontal Bone / abnormalities
Nose / abnormalities
Retrospective Studies
Twins, Dizygotic*
Twins, Monozygotic*

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