Document Detail

Cranial ultrasound scanning and prediction of outcome in newborns with congenital cytomegalovirus infection.
MedLine Citation:
PMID:  17236893     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To report the accuracy of ultrasound scanning (US) in predicting neurodevelopmental and sensorineural outcome in patients with congenital cytomegalovirus (CMV) infection. STUDY DESIGN: Fifty-seven neonates with congenital CMV infection underwent brain US and were observed prospectively for motor skills, developmental quotient, and hearing function. RESULTS: Abnormal results on US were found in 12 of 57 neonates. US lesions were more frequent in newborns with clinical and laboratory signs of congenital CMV infection at birth (10/18) than in newborns who had no symptoms at birth (2/39; P < .001). At least 1 sequela developed in all neonates with symptoms who had abnormal US results, whereas none of the neonates with symptoms who had normal US results had long-term sequelae (P < .001). In the population without symptoms, sensorineural hearing loss developed in 3 of 37 (8.1%) neonates with normal US results, whereas severe sequelae developed in 1 of 2 neonates with abnormal US results. CONCLUSIONS: A good correlation was found between cerebral US abnormalities and the prediction of outcome in newborns who were congenitally infected with CMV and had symptoms at birth. US could be performed as the first neuroimaging study in these newborns. Data are insufficient to permit any suggestions for the population without symptoms.
Gina Ancora; Marcello Lanari; Tiziana Lazzarotto; Valentina Venturi; Elisabetta Tridapalli; Fabrizio Sandri; Maddalena Menarini; Emanuela Ferretti; Giacomo Faldella
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  150     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-22     Completed Date:  2007-02-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  157-61     Citation Subset:  AIM; IM    
Institute of Neonatology, Department of Gynecological, Obstetrical, and Pediatric Sciences, Sant'Orsola Hospital, University of Bologna, Bologna, Italy.
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MeSH Terms
Birth Weight
Brain Diseases / etiology,  ultrasonography*
Cytomegalovirus Infections / complications,  congenital*,  ultrasonography*
Developmental Disabilities / ultrasonography,  virology
Gestational Age
Hearing Loss, Sensorineural / epidemiology,  virology
Infant, Newborn
Magnetic Resonance Imaging
Odds Ratio
Predictive Value of Tests
Prospective Studies
Risk Assessment
Tomography, X-Ray Computed
Ultrasonography, Doppler*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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