Document Detail


Cranial ultrasonography, CK-BB and neurological assessment as predictors of outcome in hypoxic ischaemic encephalopathy.
MedLine Citation:
PMID:  7687117     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A comparison of cranial ultrasonography, CK-BB and neurological assessment was undertaken in 30 (16 severely, 14 moderately) asphyxiated newborns. In the 16 severely asphyxiated newborns, cranial ultrasonography proved to be of value when changes of 'cerebral oedema' persisted for longer than 48 hrs. Although the mean creatine-kinase (CK-BB) activity at 12-33 hrs after birth was higher compared with that in controls of the same age, the numbers were too small in the different age categories for statistical analysis. The 81.25% specificity of ultrasound as compared with 76.47% of CK-BB suggests that the former investigation is a better indicator of cerebral injury. Phenobarbitone administered as an anticonvulsant in eight patients did not influence the CK-BB levels and the outcome in these babies. The persistence of neurological signs for more than 2 weeks predicted a poor outcome. Sixty-two per cent of the severely asphyxiated babies were light-for-dates, indicating that a chronic condition may have contributed to the poor overall prognosis in these neonates. From a combination of persisting abnormal appearances on cranial ultrasonography, elevated CK-BB activity and neurological impairment, death or significant neurological damage in nearly 90% of the severely asphyxiated babies could be predicted.
Authors:
M Adhikari; M Moodley; P K Desai
Related Documents :
18762507 - Antenatal use of selective serotonin-reuptake inhibitors and qt interval prolongation i...
6488567 - Squamous epithelium in the subglottic region of paediatric larynges.
22674387 - Comprehensive analysis of genes expressed by rare microchimeric fetal cells in the mate...
501507 - Human chorionic somatomammotropin, estriol and oxytocinase as indexes of fetal growth.
24716807 - Little beneficial effect of maternal vitamin supplement on metabolic disturbances in th...
7966037 - Low-dose follicle stimulating hormone for ovulation induction in polycystic ovary syndr...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of tropical paediatrics     Volume:  13     ISSN:  0272-4936     ISO Abbreviation:  Ann Trop Paediatr     Publication Date:  1993  
Date Detail:
Created Date:  1993-08-12     Completed Date:  1993-08-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8210625     Medline TA:  Ann Trop Paediatr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  195-200     Citation Subset:  IM    
Affiliation:
Department of Paediatrics and Child Health, Faculty of Medicine, University of Natal, Durban, South Africa.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Asphyxia Neonatorum / blood,  complications*,  ultrasonography
Brain Diseases / diagnosis,  etiology*,  mortality
Creatine Kinase / blood
Echoencephalography
Follow-Up Studies
Humans
Infant, Newborn
Isoenzymes
Neurologic Examination
Prognosis
Chemical
Reg. No./Substance:
0/Isoenzymes; EC 2.7.3.2/Creatine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Infective endocarditis in children: profile in a developing country.
Next Document:  Paediatric AIDS: first autopsy report from India.