Document Detail


Cranial nerve palsy in Wegener's granulomatosis--lessons from clinical cases.
MedLine Citation:
PMID:  19253059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The problem of diagnosing vasculitic neuropathy is discussed based on case reports of two patients with Wegener's granulomatosis. One patient developed de novo 6(th) nerve palsy as an isolated relapse manifestation and the second patient a sequence of multiple cranial nerve palsies. Brain imaging with CT and MRI and the laboratory provided no clues suggesting active vasculitis. However, in both patients the neuropathies fully recovered in response to standard induction protocols of vasculitis. In the absence of organ-specific proof of vasculitis, these treatment decisions were guided by the overall clinical presentations. Cranial neuropathy may be the first obvious vasculitic manifestation preceding other organ disease, and since single reliable tests for its diagnosis are lacking, a multidisciplinary approach is advocated here to detect vasculitic manifestations in other organs.
Authors:
Rainer Nowack; Paul Wachtler; Jürgen Kunz; Niels Rasmussen
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2009-03-01
Journal Detail:
Title:  Journal of neurology     Volume:  256     ISSN:  1432-1459     ISO Abbreviation:  J. Neurol.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-05-04     Completed Date:  2009-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  299-304     Citation Subset:  IM    
Affiliation:
Nephrology/Dialysis centre Lindau, Friedrichshafener Str. 82, 88131, Lindau, Germany. nowack@dialyse-lindau.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Brain / pathology
Cranial Nerve Diseases / diagnosis*,  etiology*,  pathology,  therapy
Diagnosis, Differential
Female
Humans
Magnetic Resonance Imaging
Male
Tomography, X-Ray Computed
Vasculitis, Central Nervous System / diagnosis*,  therapy
Wegener Granulomatosis / complications*,  diagnosis*,  pathology,  therapy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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