Document Detail


Cranial magnetic resonance imaging and school performance in very low birth weight infants in adolescence.
MedLine Citation:
PMID:  10448179     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To determine whether neurological deficits are associated with structural anomalies of the brain in very low birthweight (VLBW) infants with subsequent learning disorders but without cerebral palsy, or whether other factors, such as poor early growth, are responsible. METHODS: Eighty seven VLBW infants and eight term controls who had been examined at school between the ages of 12 and 13 years, had cranial magnetic resonance imaging (MRI) scans at 15-17 years of age. RESULTS: Thirty seven (42.5%) of the VLBW children had abnormalities reported on their scans (two porencephaly, 28 periventricular leucomalacia, 24 ventricular dilatation, and 15 thinning of the corpus callosum). No significant differences in intelligence quotient, motor clumsiness, or frequency of attention deficit / hyperactivity disorder were observed between those children with MRI lesions and those with normal scans. Quantitative measurements showed the VLBW infants had smaller brains, and a relatively smaller corpus callosum compared with controls. No association between brain measurements and school performance was observed among the VLBW infants. CONCLUSIONS: The difficulties experienced by VLBW children at school are unlikely to be the result of perinatal brain injury, but they might to be attributable to the effects of poor postnatal growth.
Authors:
R W Cooke; L J Abernethy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  81     ISSN:  1359-2998     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-09-24     Completed Date:  1999-09-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  F116-21     Citation Subset:  AIM; IM    
Affiliation:
Department of Child Health University of Liverpool Royal Liverpool Children's Hospital (Alder Hey) Liverpool L12 2AP.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Brain / pathology
Brain Diseases / diagnosis,  physiopathology,  psychology*
Cerebral Ventricles / pathology
Corpus Callosum / pathology
Dilatation, Pathologic / psychology
Follow-Up Studies
Humans
Infant, Newborn
Infant, Premature / psychology*
Infant, Very Low Birth Weight / psychology*
Intelligence
Learning Disorders / etiology*,  physiopathology
Leukomalacia, Periventricular / psychology
Magnetic Resonance Imaging
Comments/Corrections

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