Document Detail

Cranial nerve seven palsy and its influence on meibomian gland function.
MedLine Citation:
PMID:  22327637     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate a possible relationship between cranial nerve seven (CN VII) palsy and meibomian gland dysfunction.
METHODS: A prospective case series of 16 patients with unilateral CN VII palsy was evaluated for meibomian gland function. Main outcome measures included the Sunnybrook Facial Grading System for CN VII palsy and a modified version of a noncontact, noninvasive meibomian gland evaluation by Arita et al., Unaffected contralateral eyes were used as the control group for comparison.
RESULTS: Sixteen affected eyes were evaluated. The mean Sunnybrook Facial Grading System composite score was 34.19 ± 24 (score = -15 to 100; maximum function = 100). A paired samples t test between affected and unaffected eyes demonstrated a significant difference between mean values for tear break-up time, eyelid abnormality, meiboscore for upper eyelid, meiboscore for lower eyelid, combined meiboscore, and digital pressure. No significant difference was found for superficial punctate keratopathy nor Schirmer's test. A Pearson product-moment correlation coefficient found a significant negative correlation between the Sunnybrook Facial Grading System composite score and all aspects of meibomian gland function, except for the upper eyelid meiboscore, which only approached significance (p = 0.059).
CONCLUSION: These findings suggest that a strong relationship exists between cranial nerve seven palsy and meibomian gland dysfunction. Clinical optimization of meibomian gland function may benefit cranial nerve seven palsy patients.
Christopher T Shah; Andrew L Blount; Elizabeth V Nguyen; Adam S Hassan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ophthalmic plastic and reconstructive surgery     Volume:  28     ISSN:  1537-2677     ISO Abbreviation:  Ophthal Plast Reconstr Surg     Publication Date:    2012 May-Jun
Date Detail:
Created Date:  2012-05-14     Completed Date:  2012-07-20     Revised Date:  2013-05-08    
Medline Journal Info:
Nlm Unique ID:  8508431     Medline TA:  Ophthal Plast Reconstr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  166-8     Citation Subset:  IM    
Michigan State University College of Human Medicine, Grand Rapids, MI, USA.
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MeSH Terms
Eyelid Diseases / physiopathology*
Facial Nerve Diseases / physiopathology*
Fluorescein / diagnostic use
Fluorescent Dyes / diagnostic use
Meibomian Glands / physiopathology*
Prospective Studies
Tears / physiology
Reg. No./Substance:
0/Fluorescent Dyes; 2321-07-5/Fluorescein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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