| Cranberry and warfarin interaction: a case report and review of the literature. | |
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MedLine Citation:
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PMID: 22231999 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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This case reports on a patient whose International Normalized Ratio (INR) increased after ingestion of cranberry sauce while stabilized on warfarin. It is followed by a review of the published literature on the potential interaction between the two.An 85-year-old woman on chronic warfarin therapy for atrial fibrillation experienced INR elevations of two- to three-fold after two separate ingestions of cranberry sauce. In each case, her INR values decreased after withholding three to four doses and resuming a similar maintenance dose of warfarin. Although the majority of the pharmacokinetic and pharmacodynamic studies did not find a significant interaction between cranberry and warfarin, several case reports indicate that cranberry products may increase INR values in patients on warfarin. Practitioners should consider cranberry usage as a potential contributor in the evaluation of supratherapeutic INR values in patients on warfarin. |
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Authors:
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Stacy L Haber; Kimberly A B Cauthon; Erin C Raney |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists Volume: 27 ISSN: 0888-5109 ISO Abbreviation: Consult Pharm Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9013983 Medline TA: Consult Pharm Country: United States |
Other Details:
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Languages: eng Pagination: 58-65 Citation Subset: IM |
Affiliation:
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Midwestern University College of Pharmacy-Glendale, Glendale. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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