Document Detail

Cranberry and warfarin interaction: a case report and review of the literature.
MedLine Citation:
PMID:  22231999     Owner:  NLM     Status:  In-Data-Review    
This case reports on a patient whose International Normalized Ratio (INR) increased after ingestion of cranberry sauce while stabilized on warfarin. It is followed by a review of the published literature on the potential interaction between the two.An 85-year-old woman on chronic warfarin therapy for atrial fibrillation experienced INR elevations of two- to three-fold after two separate ingestions of cranberry sauce. In each case, her INR values decreased after withholding three to four doses and resuming a similar maintenance dose of warfarin. Although the majority of the pharmacokinetic and pharmacodynamic studies did not find a significant interaction between cranberry and warfarin, several case reports indicate that cranberry products may increase INR values in patients on warfarin. Practitioners should consider cranberry usage as a potential contributor in the evaluation of supratherapeutic INR values in patients on warfarin.
Stacy L Haber; Kimberly A B Cauthon; Erin C Raney
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists     Volume:  27     ISSN:  0888-5109     ISO Abbreviation:  Consult Pharm     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013983     Medline TA:  Consult Pharm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  58-65     Citation Subset:  IM    
Midwestern University College of Pharmacy-Glendale, Glendale.
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