Document Detail


The [(Cp)M(CO)(3) ] (M=Re, (99m) Tc) Building Block for Imaging Agents and Bioinorganic Probes: Perspectives and Limitations.
MedLine Citation:
PMID:  22976975     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Starting from asymmetric Thiele's acid derivatives, two different imaging probes [(99m) Tc(CO)(3) (CpR)] (R=potential targeting vector) are generated simultaneously in one-pot and from one substrate. This extends the previously introduced labeling strategy of metal-mediated retro-DielsAlder reaction with HCp-R dimers. We demonstrate that chemically active functionalities such as hydroxamic acids are not following this labeling strategy. Adopting the principle of replacing phenyl rings by [Re(CO)(3) (Cp)] entities, potent histone deacetylase (HDAC)-inhibiting Re analogs of suberoylanlilide hydroxamic acid (SAHA; N-hydroxy-N'-phenyloctanediamide) were synthesized and characterized. Cytotoxic evaluation on different tumor cell lines revealed low IC(50) values [μM] for these compounds, comparable to their purely organic congeners.
Authors:
Daniel Can; Harmel W Peindy N'dongo; Bernhard Spingler; Paul Schmutz; Paula Raposinho; Isabel Santos; Roger Alberto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemistry & biodiversity     Volume:  9     ISSN:  1612-1880     ISO Abbreviation:  Chem. Biodivers.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101197449     Medline TA:  Chem Biodivers     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  1849-66     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Verlag Helvetica Chimica Acta AG, Zürich.
Affiliation:
Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, (phone: +41 44 63 54631).
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