| CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9. | |
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MedLine Citation:
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PMID: 20178773 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We previously reported the strong immunostimulatory effects of a CpG oligodeoxynucleotide (ODN), designated MsST, from the lacZ gene of Streptococcus (S.) thermophilus ATCC19258. Here we show that 24h of stimulation with MsST in mouse splenocytes and peritoneal macrophages strongly induces expression of interleukin (IL)-33, a cytokine in the IL-1 superfamily. Other IL-1 superfamily members, including IL-1alpha, IL-1beta and IL-18, are down-regulated after 24h of stimulation of MsST. We also found that MsST-induced IL-33 mRNA expression is inhibited by the suppressive ODN A151, which can inhibit Toll-like receptor 9 (TLR9)-mediated responses. This is the first report to show that IL-33 can be induced by CpG ODNs. The strong induction of IL-33 by MsST suggests that it may be a potential therapeutic ODN for the treatment of inflammatory disease. The presence of a strong CpG ODN in S. thermophilus also suggests that the bacterium may be a good candidate as a starter culture for the development of new physiologically functional foods. |
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Authors:
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Takeshi Shimosato; Megumi Fujimoto; Masanori Tohno; Takashi Sato; Mariko Tateo; Hajime Otani; Haruki Kitazawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-21 |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 394 ISSN: 1090-2104 ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-29 Completed Date: 2010-04-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 81-6 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Fiber-Nanotech Young Researcher Empowerment Center, Shinshu University, Minamiminowa 399-4598, Japan. shimot@shinshu-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals CpG Islands / immunology* Immunologic Factors / pharmacology* Immunomodulation Interleukins / biosynthesis* Lac Operon / immunology Macrophages, Peritoneal / drug effects*, immunology Male Mice Mice, Inbred C57BL Oligodeoxyribonucleotides / immunology, pharmacology* Streptococcus thermophilus / genetics, immunology* Toll-Like Receptor 9 / metabolism* Up-Regulation beta-Galactosidase / genetics |
| Chemical | |
Reg. No./Substance:
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0/Immunologic Factors; 0/Interleukins; 0/Oligodeoxyribonucleotides; 0/Tlr9 protein, mouse; 0/Toll-Like Receptor 9; 0/interleukin-33, mouse; EC 3.2.1.23/beta-Galactosidase |
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