Document Detail

Coxsackievirus group B antibodies in the ventricular fluid of infants with severe anatomic defects in the central nervous system.
MedLine Citation:
PMID:  2989763     Owner:  NLM     Status:  MEDLINE    
Ventricular fluids from four of 28 newborn infants who were initially seen with severe congenital anatomic defects in the central nervous system contained neutralizing antibody to at least one serotype of coxsackieviruses group B. Two of the four infants with anti-coxsackieviruses group B antibody in the ventricular fluid did not have a detectable level of the same antibody(ies) in their serum. The ventricular fluid of one of the infants had immunoglobulin M neutralizing antibody directed against coxsackievirus B6. Of 11 mother-infant pairs that had neutralizing antibody to coxsackieviruses group B in both sera, nearly half had antibodies directed against more than one serotype. These data suggest the possibility of an association between congenital infections with coxsackieviruses group B and rare severe CNS defects.
C J Gauntt; R J Gudvangen; Y W Brans; A E Marlin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics     Volume:  76     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1985 Jul 
Date Detail:
Created Date:  1985-08-12     Completed Date:  1985-08-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  64-8     Citation Subset:  AIM; IM    
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MeSH Terms
Antibodies, Viral / cerebrospinal fluid*
Brain / abnormalities*,  microbiology
Cerebral Ventricles
Cytopathogenic Effect, Viral
Enterovirus B, Human / immunology*,  isolation & purification
Hydrocephalus / immunology
Infant, Newborn
Reg. No./Substance:
0/Antibodies, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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