| Coxsackievirus group B antibodies in the ventricular fluid of infants with severe anatomic defects in the central nervous system. | |
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MedLine Citation:
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PMID: 2989763 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ventricular fluids from four of 28 newborn infants who were initially seen with severe congenital anatomic defects in the central nervous system contained neutralizing antibody to at least one serotype of coxsackieviruses group B. Two of the four infants with anti-coxsackieviruses group B antibody in the ventricular fluid did not have a detectable level of the same antibody(ies) in their serum. The ventricular fluid of one of the infants had immunoglobulin M neutralizing antibody directed against coxsackievirus B6. Of 11 mother-infant pairs that had neutralizing antibody to coxsackieviruses group B in both sera, nearly half had antibodies directed against more than one serotype. These data suggest the possibility of an association between congenital infections with coxsackieviruses group B and rare severe CNS defects. |
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Authors:
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C J Gauntt; R J Gudvangen; Y W Brans; A E Marlin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatrics Volume: 76 ISSN: 0031-4005 ISO Abbreviation: Pediatrics Publication Date: 1985 Jul |
Date Detail:
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Created Date: 1985-08-12 Completed Date: 1985-08-12 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 64-8 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Viral
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cerebrospinal fluid* Brain / abnormalities*, microbiology Cerebral Ventricles Cytopathogenic Effect, Viral Enterovirus B, Human / immunology*, isolation & purification Humans Hydrocephalus / immunology Infant, Newborn |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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