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Cow's Milk Allergy Is a Major Contributor in Recurrent Perianal Dermatitis of Infants.
MedLine Citation:
PMID:  22988522     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Background. Recurrent perianal inflammation has great etiologic diversity. A possible cause is cow's milk allergy (CMA). The aim was to assess the magnitude of this cause. Subjects and Methods. This follow up clinical study was carried out on 63 infants with perianal dermatitis of more than 3 weeks with history of recurrence. Definitive diagnosis was made for each infant through medical history taking, clinical examination and investigations including stool analysis and culture, stool pH and reducing substances, perianal swab for different cultures and staining for Candida albicans. Complete blood count and quantitative determination of cow's milk-specific serum IgE concentration were done for all patients. CMA was confirmed through an open withdrawal-rechallenge procedure. Serum immunoglobulins and CD markers as well as gastrointestinal endoscopies were done for some patients. Results. Causes of perianal dermatitis included CMA (47.6%), bacterial dermatitis (17.46%), moniliasis (15.87%), enterobiasis (9.52%) and lactose intolerance (9.5%). Predictors of CMA included presence of bloody and/or mucoid stool, other atopic manifestations, anal fissures, or recurrent vomiting. Conclusion. We can conclude that cow's milk allergy is a common cause of recurrent perianal dermatitis. Mucoid or bloody stool, anal fissures or ulcers, vomiting and atopic manifestations can predict this etiology.
Authors:
Mostafa Abdel-Aziz El-Hodhod; Ahmad Mohamed Hamdy; Marwa Talaat El-Deeb; Mohamed O Elmaraghy
Publication Detail:
Type:  Journal Article     Date:  2012-09-03
Journal Detail:
Title:  ISRN pediatrics     Volume:  2012     ISSN:  2090-4703     ISO Abbreviation:  ISRN Pediatr     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-18     Completed Date:  2012-09-19     Revised Date:  2013-04-02    
Medline Journal Info:
Nlm Unique ID:  101568077     Medline TA:  ISRN Pediatr     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  408769     Citation Subset:  -    
Affiliation:
Department of Pediatrics, Faculty of Medicine, Ain Shams University, Abbassia, Cairo 11566, Egypt.
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