| Cowden's disease: analysis of fourteen new cases. | |
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MedLine Citation:
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PMID: 6512057 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fourteen new patients with Cowden's disease from the Netherlands were analyzed and compared with the sixty-nine previously reported patients. The full clinical spectrum of the disease can now be fairly well delineated. Mucocutaneous lesions, especially facial trichilemmomas and other follicular malformations, acral keratoses, and oral papillomas, remain the most constant findings. The incidence of each of these mucocutaneous findings was slightly higher than reported previously, probably reflecting increasing experience with this condition. Also our patients tended to have more extensive acral keratoses and perhaps less extensive facial lesions. In one family there was an extremely high incidence of lipomas. Breast cancer was seen in three of our twelve female patients, reflecting the trend toward a lower incidence of breast cancer in the recent literature. Gastrointestinal polyps in one family were much more common than previously reported, occurring in five of seven patients. Thyroid disease was found in about two thirds of the patients and abnormalities of the female reproductive system in slightly more than half of the patients, both incidences being approximately the same as in the literature. With increased awareness of the condition it is likely that many more cases will be recognized in the future. |
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Authors:
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T M Starink |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of the American Academy of Dermatology Volume: 11 ISSN: 0190-9622 ISO Abbreviation: J. Am. Acad. Dermatol. Publication Date: 1984 Dec |
Date Detail:
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Created Date: 1985-02-05 Completed Date: 1985-02-05 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7907132 Medline TA: J Am Acad Dermatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1127-41 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Bone and Bones / abnormalities Breast Neoplasms / genetics Congenital Abnormalities / genetics Eye Diseases / genetics Facial Neoplasms / genetics Female Gastrointestinal Neoplasms / genetics Genes, Dominant* Hamartoma / genetics* Humans Male Middle Aged Mouth Neoplasms / genetics Neoplasms, Multiple Primary / genetics* Netherlands Papilloma / genetics Skin Neoplasms / genetics* Syndrome Thyroid Neoplasms / genetics |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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