Document Detail


Cowden syndrome with bronchial asthma.
MedLine Citation:
PMID:  20718196     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cowden's syndrome (CS) is a rare autosomal dominant disorder characterized by multiple hamartomas and an increased risk of breast, thyroid and endometrial carcinomas. Mutations of tumor suppressor gene PTEN (phosphatase and tensin homolog) on chromosome 10p23.2, which encodes a lipid phosphatase mediating cell cycle arrest and apoptosis, were first described in CS. Some studies have also implicated PTEN in the pathogenesis of bronchial asthma. Herein, we describe a boy with CS referred to the pediatric allergy unit with bronchial asthma symptoms. This patient is one of the very few reported cases with CS with lung disease and possibly the first with bronchial asthma.
Authors:
Yasemin Ozsürekci; Süleyman Tolga Yavuz; Yasemin Alanay; Gülen Eda Utine; Omer Kalayci
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Turkish journal of pediatrics     Volume:  52     ISSN:  0041-4301     ISO Abbreviation:  Turk. J. Pediatr.     Publication Date:    2010 May-Jun
Date Detail:
Created Date:  2010-08-19     Completed Date:  2010-09-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417505     Medline TA:  Turk J Pediatr     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  330-2     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Asthma / complications*
Child
Hamartoma Syndrome, Multiple / complications*,  diagnosis
Humans
Male

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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