Document Detail

Cow milk feeding in infancy: further observations on blood loss from the gastrointestinal tract.
MedLine Citation:
PMID:  2295949     Owner:  NLM     Status:  MEDLINE    
Because feeding of cow milk causes normal infants to lose increased amounts of occult blood from the gastrointestinal tract, we conducted a prospective trial to measure intestinal blood loss quantitatively and to monitor iron nutritional status. Fifty-two infants entered the trial at 168 days of age and were assigned at random to receive either cow milk or a milk-based formula. Initially, 31 infants had been breast-fed and 21 had been fed formulas. With the feeding of cow milk, the proportion of guaiac-positive stools increased from 3.0% at baseline to 30.3% during the first 28 days of the trial (p less than 0.01), whereas the proportion of positive stools remained low (5.0%) with the feeding of formula. The proportion of guaiac-positive stools among cow milk-fed infants declined later, but for the entire trial it remained significantly (p less than 0.01) elevated. Stool hemoglobin concentration increased markedly with the introduction of cow milk, rising from a mean (+/- SD) of 622 +/- 527 micrograms/gm dry stool at baseline to 3598 +/- 10,479 micrograms/gm dry stool during the first 28 days of ingestion of cow milk. Among infants fed formula, stool hemoglobin did not increase and was significantly (p less than 0.01) less than in the cow milk group. Among infants fed cow milk, the increase in hemoglobin concentration tended to be greater for those who had initially been fed human milk than for those who had initially been fed formulas. Iron nutritional status was not significantly different between the two feeding groups. However, one infant became iron deficient after 4 weeks of ingesting cow milk. We conclude that cow milk feeding leads to increased intestinal tract blood loss in a large proportion of normal infants and that the amount of iron lost is nutritionally important.
E E Ziegler; S J Fomon; S E Nelson; C J Rebouche; B B Edwards; R R Rogers; L J Lehman
Related Documents :
19054929 - A quantitative and relative increase in intestinal bacteroides in allergic infants in r...
21214609 - In vitro measurement of the impact of human milk oligosaccharides on the faecal microbi...
9655569 - Reproductive performance, calf growth, and milk production of first-calf heifers sired ...
2705659 - Anaphylactic reactions to a cow's milk whey protein hydrolysate (alfa-ré, nestlé) in ...
18492839 - Early dietary intervention with a mixture of prebiotic oligosaccharides reduces the inc...
18626199 - Interaction of early infant feeding, heredity and other environmental factors as determ...
15461009 - Trends in socioeconomic inequalities in mortality in developing countries: the case of ...
15371779 - Outcome analysis of prenatally detected ureteroceles associated with multicystic dyspla...
24906549 - Placental pathologic changes of maternal vascular underperfusion in bronchopulmonary dy...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  116     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-02-14     Completed Date:  1990-02-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  11-8     Citation Subset:  AIM; IM    
Department of Pediatrics, University of Iowa, Iowa City 52242.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Feces / analysis
Guaiac / analysis
Hemoglobins / analysis
Infant Food / adverse effects*
Infant, Newborn
Iron / deficiency
Milk / adverse effects*
Nutritional Status
Occult Blood*
Prospective Studies
Random Allocation
Reference Values
Grant Support
Reg. No./Substance:
0/Hemoglobins; 7439-89-6/Iron; 9000-29-7/Guaiac

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Iodophenylpentadecanoic acid-myocardial blood flow relationship during maximal exercise with coronar...
Next Document:  Eight-year school performance and growth of preterm, small for gestational age infants: a comparativ...