Document Detail

Covered skin transcutaneous bilirubin estimation is comparable with serum bilirubin during and after phototherapy.
MedLine Citation:
PMID:  21818063     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether transcutaneous bilirubin (TcB) from covered skin (TcB-C) during and after discontinuing phototherapy (PHT) is reliable in treating neonatal jaundice.
STUDY DESIGN: In this prospective observational study, before starting PHT, part of the forehead was covered. TcB-C and TcB from exposed skin (TcB-E) to PHT were measured before starting PHT, on a 12-hourly basis while receiving PHT and 6 h after stopping PHT. We used ANOVA (analysis of variance) and Bonferroni's t-tests.
RESULT: A total of 39 infants were enrolled (mean gestation 39 weeks, 51% males and 80% Hispanic). The mean TSB over all time periods was 10.9±2.4, TcB-C 10.9±2.4 and TcB-E 7.2±3.4. Before PHT, there were no significant differences in bilirubin by all three techniques. TcB-C was not significantly different from TSB at any time point. However, TcB-E was significantly lower during PHT and after stopping PHT.
CONCLUSION: TcB-C is a reliable method in the management of neonatal jaundice.
R Fonseca; R Kyralessa; M Malloy; J Richardson; S K Jain
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2011-08-04
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  32     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-31     Completed Date:  2012-06-04     Revised Date:  2012-10-24    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  129-31     Citation Subset:  IM    
Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555, USA.
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MeSH Terms
Bilirubin / analysis*,  blood
Biological Markers / analysis
Cohort Studies
Follow-Up Studies
Gestational Age
Infant, Newborn
Infant, Premature
Intensive Care Units, Neonatal
Jaundice, Neonatal / diagnosis*,  therapy*
Monitoring, Physiologic / methods
Phototherapy / methods*
Prospective Studies
Reproducibility of Results
Sensitivity and Specificity
Severity of Illness Index
Skin / chemistry*
Treatment Outcome
Reg. No./Substance:
0/Biological Markers; 635-65-4/Bilirubin
Comment In:
J Perinatol. 2012 Sep;32(9):734-5; author reply 735   [PMID:  22931963 ]

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